UC Santa Cruz

Two recent articles were written in response to our paper Breaking RAD: An evaluation of the utility of restriction site associated DNA sequencing scans of adaptation. While we agree with some of the comments made by the authors of these two response papers, we still believe caution should be employed in RADseq studies that aim to detect loci that contribute to adaptation. In this rebuttal, we evaluate the key points made in these papers, attempt to identify a middle ground and make suggestions for responsibly conducting future studies to understand the genomewide mechanisms of adaptation.