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Spotlight on CRISPR in Strongyloides Parasitic Nematodes
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https://doi.org/10.1016/j.pt.2017.11.005Abstract
Parasitic nematodes are biomedically and economically important, but many are genetically intractable which limits our understanding of their molecular and cellular biology. Gang et al. report CRISPR/Cas9 genome editing in parasites of the genus Strongyloides, generating both knock-outs and knock-ins, and demonstrated heritability of the modifications, a crucial advance in the field.
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