Effects of blood type and number concentration on the circulation time of micro-sized erythrocyte-derived optical particles in mice
Abstract
Erythrocyte-derived optical microparticles containing near infrared (NIR) dyes such as indocyanine green (ICG) present a promising platform for fluorescence imaging and laser treatment of abnormal vasculature, including port wine birthmarks. Herein, we have investigated the effects of blood type utilized in fabricating these microparticles, and the number density of the particles on their circulation time in mice by real-time NIR fluorescence imaging of the dermal vasculature. We find that the emission half-life of microparticles engineered from human O+ blood type increases by approximately two-fold as compared to those engineered from B+ blood type. Increasing the number density of the microparticles fabricated from O+ blood type from ~0.5 millions/µl to 1.6 millions/µl is associated with nearly a fourfold increase in the emission half-life of the particles. These findings emphasize the importance of blood type and number density in engineering erythrocyte-derived particles for clinical applications as treatment of PWBs.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.