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Decrease post-transplant relapse using donor-derived expanded NK-cells
- Ciurea, Stefan O;
- Kongtim, Piyanuch;
- Soebbing, Doris;
- Trikha, Prashant;
- Behbehani, Gregory;
- Rondon, Gabriela;
- Olson, Amanda;
- Bashir, Qaiser;
- Gulbis, Alison M;
- Indreshpal, Kaur;
- Rezvani, Katayoun;
- Shpall, Elizabeth J;
- Bassett, Roland;
- Cao, Kai;
- Martin, Andrew St;
- Devine, Steven;
- Horowitz, Mary;
- Pasquini, Marcelo;
- Lee, Dean A;
- Champlin, Richard E
- et al.
Published Web Location
https://doi.org/10.1038/s41375-021-01349-4Abstract
In this phase I/II clinical trial, we investigated the safety and efficacy of high doses of mb-IL21 ex vivo expanded donor-derived NK cells to decrease relapse in 25 patients with myeloid malignancies receiving haploidentical stem-cell transplantation (HSCT). Three doses of donor NK cells (1 × 105-1 × 108 cells/kg/dose) were administered on days -2, +7, and +28. Results were compared with an independent contemporaneously treated case-matched cohort of 160 patients from the CIBMTR database.After a median follow-up of 24 months, the 2-year relapse rate was 4% vs. 38% (p = 0.014), and disease-free survival (DFS) was 66% vs. 44% (p = 0.1) in the cases and controls, respectively. Only one relapse occurred in the study group, in a patient with the high level of donor-specific anti-HLA antibodies (DSA) presented before transplantation. The 2-year relapse and DFS in patients without DSA was 0% vs. 40% and 72% vs. 44%, respectively with HR for DFS in controls of 2.64 (p = 0.029). NK cells in recipient blood were increased at day +30 in a dose-dependent manner compared with historical controls, and had a proliferating, mature, highly cytotoxic, NKG2C+/KIR+ phenotype.Administration of donor-derived expanded NK cells after haploidentical transplantation was safe, associated with NK cell-dominant immune reconstitution early post-transplant, preserved T-cell reconstitution, and improved relapse and DFS. TRIAL REGISTRATION: NCT01904136 ( https://clinicaltrials.gov/ct2/show/NCT01904136 ).
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