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Androgen Receptor Inhibition Increases MHC Class I Expression and Improves Immune Response in Prostate Cancer
- Chesner, Lisa N;
- Polesso, Fanny;
- Graff, Julie N;
- Hawley, Jessica E;
- Smith, Alexis K;
- Lundberg, Arian;
- Das, Rajdeep;
- Shenoy, Tanushree;
- Sjöström, Martin;
- Zhao, Faming;
- Hu, Ya-Mei;
- Linder, Simon;
- Chen, William S;
- Hawkins, Reed M;
- Shrestha, Raunak;
- Zhu, Xiaolin;
- Foye, Adam;
- Li, Haolong;
- Kim, Lisa M;
- Bhalla, Megha;
- O’loughlin, Thomas;
- Kuzuoglu-Ozturk, Duygu;
- Hua, Junjie T;
- Badura, Michelle L;
- Wilkinson, Scott;
- Trostel, Shana Y;
- Bergman, Andries M;
- Ruggero, Davide;
- Drake, Charles G;
- Sowalsky, Adam G;
- Fong, Lawrence;
- Cooperberg, Matthew R;
- Zwart, Wilbert;
- Guan, Xiangnan;
- Ashworth, Alan;
- Xia, Zheng;
- Quigley, David A;
- Gilbert, Luke A;
- Feng, Felix Y;
- Moran, Amy E
- et al.
Published Web Location
https://doi.org/10.1158/2159-8290.cd-24-0559Abstract
Significance
Immunotherapy options for immune cold tumors, like prostate cancer, are limited. We show that AR downregulates MHCI expression/antigen presentation and that AR inhibition improves T-cell responses and tumor control. This suggests that treatments combining AR inhibitors and checkpoint blockade may improve tumor immune surveillance and antitumor immunity in patients.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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