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Comparative RNA-seq analysis aids in diagnosis of a rare pediatric tumor
- Sanders, Lauren M;
- Rangaswami, Arun;
- Bjork, Isabel;
- Lam, Du Linh;
- Beale, Holly C;
- Kephart, Ellen Towle;
- Durbin, Ann;
- Learned, Katrina;
- Currie, Rob;
- Lyle, A Geoffrey;
- Pfeil, Jacob;
- Shah, Avanthi Tayi;
- Lee, Alex G;
- Leung, Stanley G;
- Behroozfard, Inge H;
- Breese, Marcus R;
- Peralez, Jennifer;
- Hazard, Florette K;
- Lacayo, Norman;
- Spunt, Sheri L;
- Haussler, David;
- Salama, Sofie R;
- Sweet-Cordero, E Alejandro;
- Vaske, Olena M
- et al.
Published Web Location
https://doi.org/10.1101/mcs.a004317Abstract
Gliomatosis peritonei is a rare pathologic finding that is associated with ovarian teratomas and malignant mixed germ cell tumors. The occurrence of gliomatosis as a mature glial implant can impart an improved prognosis to patients with immature ovarian teratoma, making prompt and accurate diagnosis important. We describe a case of recurrent immature teratoma in a 10-yr-old female patient, in which comparative analysis of the RNA sequencing gene expression data from the patient's tumor was used effectively to aid in the diagnosis of gliomatosis peritonei.
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