- Main
Impact of Human Leukocyte Antigen Allele-Killer Cell Immunoglobulin-like Receptor Partners on Sexually Transmitted Human Immunodeficiency Virus Type 1 Infection.
- Serrano-Rísquez, Carmen;
- Omar, Mohamed;
- Rallón, Norma;
- Benito, José;
- Gómez-Vidal, Amparo;
- Márquez, Francisco;
- Alján, Martina;
- Rivero-Juárez, Antonio;
- Pérez-Valero, Ignacio;
- Rivero, Antonio;
- Sinangil, Faruk;
- Saulle, Irma;
- Biasin, Mara;
- Clerici, Mario;
- Forthal, Donald;
- Saéz, Maria;
- Caruz, Antonio
- et al.
Published Web Location
https://doi.org/10.1093/infdis/jiae436Abstract
Human leukocyte antigen (HLA) class I/killer cell immunoglobulin-like receptor (KIR) genotypes influence human immunodeficiency virus type 1 (HIV-1) disease progression and viral load, but their role in primary infection is uncertain. Inconsistent results from previous studies suggest that the inoculum size and transmission route-parenteral versus sexual-may influence this association. We conducted a genome-wide association study in a population of people with HIV-1 and HIV-1-exposed seronegative individuals exposed to the virus through the sexual route. Our data do not support any role of the HLA/KIR system in susceptibility to sexually transmitted HIV-1 infection. The genetics basis of HIV-1 viral load and disease progression are distinct from the genetics of HIV resistance, a paradox worth exploring.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
Enter the password to open this PDF file:
-
-
-
-
-
-
-
-
-
-
-
-
-
-