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Immunological memory to SARS-CoV-2 assessed for up to eight months after infection
- Dan, Jennifer M;
- Mateus, Jose;
- Kato, Yu;
- Hastie, Kathryn M;
- Yu, Esther Dawen;
- Faliti, Caterina E;
- Grifoni, Alba;
- Ramirez, Sydney I;
- Haupt, Sonya;
- Frazier, April;
- Nakao, Catherine;
- Rayaprolu, Vamseedhar;
- Rawlings, Stephen A;
- Peters, Bjoern;
- Krammer, Florian;
- Simon, Viviana;
- Saphire, Erica Ollmann;
- Smith, Davey M;
- Weiskopf, Daniela;
- Sette, Alessandro;
- Crotty, Shane
- et al.
Published Web Location
https://doi.org/10.1101/2020.11.15.383323Abstract
Understanding immune memory to SARS-CoV-2 is critical for improving diagnostics and vaccines, and for assessing the likely future course of the COVID-19 pandemic. We analyzed multiple compartments of circulating immune memory to SARS-CoV-2 in 254 samples from 188 COVID-19 cases, including 43 samples at ≥ 6 months post-infection. IgG to the Spike protein was relatively stable over 6+ months. Spike-specific memory B cells were more abundant at 6 months than at 1 month post symptom onset. SARS-CoV-2-specific CD4 + T cells and CD8 + T cells declined with a half-life of 3-5 months. By studying antibody, memory B cell, CD4 + T cell, and CD8 + T cell memory to SARS-CoV-2 in an integrated manner, we observed that each component of SARS-CoV-2 immune memory exhibited distinct kinetics.
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