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Sampling of tissue volume by frequency-domain photon migration
Abstract
The tissue volume sampling by steady=state and frequency-domain photon migration was analyzed using Monte Carlo simulations. The Monte-Carlo-based method determines shape and location of photon sampling volume in homogeneous media. The difference in tissue sampling offered by steady-state and frequency domain methods was observed to be small for modulation frequencies smaller than 600 MHz. The results show impact of localized absorption heterogeneities on detected signal indicating that phase and amplitude of detected photon density exhibit spatial sensitivity characteristics.
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