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The impact of age-related hypomethylated DNA on immune signaling upon cellular demise

Published Web Location

https://doi.org/10.1016/j.it.2021.04.005
Abstract

Aging is associated with decreased antigen-specific immunity and increased chronic inflammation. While DNA-sensing pathways might be involved, the molecular factors underlying these age-related aberrancies in immune signaling are unclear. Here, we consider the potential role of aging-induced hypomethylated DNA as a putative stimulant of age-associated inflammation.

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