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Better verbal memory in women than men in MCI despite similar levels of hippocampal atrophy
- Sundermann, Erin E;
- Biegon, Anat;
- Rubin, Leah H;
- Lipton, Richard B;
- Mowrey, Wenzhu;
- Landau, Susan;
- Maki, Pauline M;
- Weiner, Michael;
- Aisen, Paul;
- Weiner, Michael;
- Aisen, Paul;
- Petersen, Ronald;
- Jack, Clifford R;
- Jagust, William;
- Trojanowki, John Q;
- Toga, Arthur W;
- Beckett, Laurel;
- Green, Robert C;
- Saykin, Andrew J;
- Morris, John;
- Liu, Enchi;
- Green, Robert C;
- Montine, Tom;
- Petersen, Ronald;
- Aisen, Paul;
- Gamst, Anthony;
- Thomas, Ronald G;
- Donohue, Michael;
- Walter, Sarah;
- Gessert, Devon;
- Sather, Tamie;
- Beckett, Laurel;
- Harvey, Danielle;
- Gamst, Anthony;
- Donohue, Michael;
- Kornak, John;
- Jack, Clifford R;
- Dale, Anders;
- Bernstein, Matthew;
- Felmlee, Joel;
- Fox, Nick;
- Thompson, Paul;
- Schuff, Norbert;
- Alexander, Gene;
- DeCarli, Charles;
- Jagust, William;
- Bandy, Dan;
- Koeppe, Robert A;
- Foster, Norm;
- Reiman, Eric M;
- Chen, Kewei;
- Mathis, Chet;
- Morris, John;
- Cairns, Nigel J;
- Taylor-Reinwald, Lisa;
- Trojanowki, JQ;
- Shaw, Les;
- Lee, Virginia MY;
- Korecka, Magdalena;
- Toga, Arthur W;
- Crawford, Karen;
- Neu, Scott;
- Saykin, Andrew J;
- Foroud, Tatiana M;
- Potkin, Steven;
- Shen, Li;
- Kachaturian, Zaven;
- Frank, Richard;
- Snyder, Peter J;
- Molchan, Susan;
- Kaye, Jeffrey;
- Quinn, Joseph;
- Lind, Betty;
- Dolen, Sara;
- Schneider, Lon S;
- Pawluczyk, Sonia;
- Spann, Bryan M;
- Brewer, James;
- Vanderswag, Helen;
- Heidebrink, Judith L;
- Lord, Joanne L;
- Petersen, Ronald;
- Johnson, Kris;
- Doody, Rachelle S;
- Villanueva-Meyer, Javier;
- Chowdhury, Munir;
- Stern, Yaakov;
- Honig, Lawrence S;
- Bell, Karen L;
- Morris, John C;
- Ances, Beau;
- Carroll, Maria;
- Leon, Sue;
- Mintun, Mark A;
- Schneider, Stacy;
- Marson, Daniel;
- Griffith, Randall;
- Clark, David;
- Grossman, Hillel;
- Mitsis, Effie;
- Romirowsky, Aliza;
- deToledo-Morrell, Leyla;
- Shah, Raj C;
- Duara, Ranjan;
- Varon, Daniel;
- Roberts, Peggy;
- Albert, Marilyn;
- Onyike, Chiadi;
- Kielb, Stephanie;
- Rusinek, Henry;
- de Leon, Mony J;
- Glodzik, Lidia;
- De Santi, Susan;
- Doraiswamy, P Murali;
- Petrella, Jeffrey R;
- Coleman, R Edward;
- Arnold, Steven E;
- Karlawish, Jason H;
- Wolk, David;
- Smith, Charles D;
- Jicha, Greg;
- Hardy, Peter;
- Lopez, Oscar L;
- Oakley, MaryAnn;
- Simpson, Donna M;
- Porsteinsson, Anton P;
- Goldstein, Bonnie S;
- Martin, Kim;
- Makino, Kelly M;
- Ismail, M Saleem;
- Brand, Connie;
- Mulnard, Ruth A;
- Thai, Gaby;
- Mc-Adams-Ortiz, Catherine;
- Womack, Kyle;
- Mathews, Dana;
- Quiceno, Mary;
- Diaz-Arrastia, Ramon;
- King, Richard;
- Weiner, Myron;
- Martin-Cook, Kristen;
- DeVous, Michael;
- Levey, Allan I;
- Lah, James J;
- Cellar, Janet S;
- Burns, Jeffrey M;
- Anderson, Heather S;
- Swerdlow, Russell H;
- Apostolova, Liana;
- Lu, Po H;
- Bartzokis, George;
- Silverman, Daniel HS;
- Graff-Radford, Neill R;
- Parfitt, Francine;
- Johnson, Heather;
- Farlow, Martin R;
- Hake, Ann Marie;
- Matthews, Brandy R;
- Herring, Scott;
- van Dyck, Christopher H;
- Carson, Richard E;
- MacAvoy, Martha G;
- Chertkow, Howard;
- Bergman, Howard;
- Hosein, Chris;
- Black, Sandra;
- Stefanovic, Bojana;
- Caldwell, Curtis;
- Robin Hsiung, Ging-Yuek;
- Feldman, Howard;
- Mudge, Benita;
- Assaly, Michele;
- Kertesz, Andrew;
- Rogers, John;
- Trost, Dick;
- Bernick, Charles;
- Munic, Donna;
- Kerwin, Diana;
- Mesulam, Marek-Marsel;
- Lipowski, Kristina;
- Wu, Chuang-Kuo;
- Johnson, Nancy;
- Sadowsky, Carl;
- Martinez, Walter;
- Villena, Teresa;
- Turner, Raymond Scott;
- Johnson, Kathleen;
- Reynolds, Brigid;
- Sperling, Reisa A;
- Johnson, Keith A;
- Marshall, Gad;
- Frey, Meghan;
- Yesavage, Jerome;
- Taylor, Joy L;
- Lane, Barton;
- Rosen, Allyson;
- Tinklenberg, Jared;
- Sabbagh, Marwan;
- Belden, Christine;
- Jacobson, Sandra;
- Kowall, Neil;
- Killiany, Ronald;
- Budson, Andrew E;
- Norbash, Alexander;
- Johnson, Patricia Lynn;
- Obisesan, Thomas O;
- Wolday, Saba;
- Bwayo, Salome K;
- Lerner, Alan;
- Hudson, Leon;
- Ogrocki, Paula;
- Fletcher, Evan;
- Carmichael, Owen;
- Olichney, John;
- DeCarli, Charles;
- Kittur, Smita;
- Borrie, Michael;
- Lee, T-Y;
- Bartha, Rob;
- Johnson, Sterling;
- Asthana, Sanjay;
- Carlsson, Cynthia M;
- Potkin, Steven G;
- Preda, Adrian;
- Nguyen, Dana;
- Tariot, Pierre;
- Fleisher, Adam;
- Reeder, Stephanie;
- Bates, Vernice;
- Capote, Horacio;
- Rainka, Michelle;
- Scharre, Douglas W;
- Kataki, Maria;
- Zimmerman, Earl A;
- Celmins, Dzintra;
- Brown, Alice D;
- Pearlson, Godfrey D;
- Blank, Karen;
- Anderson, Karen;
- Saykin, Andrew J;
- Santulli, Robert B;
- Schwartz, Eben S;
- Sink, Kaycee M;
- Williamson, Jeff D;
- Garg, Pradeep;
- Watkins, Franklin;
- Ott, Brian R;
- Querfurth, Henry;
- Tremont, Geoffrey;
- Salloway, Stephen;
- Malloy, Paul;
- Correia, Stephen;
- Rosen, Howard J;
- Miller, Bruce L;
- Mintzer, Jacobo;
- Longmire, Crystal Flynn;
- Spicer, Kenneth;
- Finger, Elizabether;
- Rachinsky, Irina;
- Rogers, John;
- Kertesz, Andrew;
- Drost, Dick;
- Pomara, Nunzio;
- Hernando, Raymundo;
- Sarrael, Antero;
- Schultz, Susan K;
- Boles Ponto, Laura L;
- Shim, Hyungsub;
- Smith, Karen Elizabeth;
- Relkin, Norman;
- Chaing, Gloria;
- Raudin, Lisa;
- Smith, Amanda;
- Fargher, Kristin;
- Ashok Raj, Balebail
- et al.
Published Web Location
https://doi.org/10.1212/wnl.0000000000002570Abstract
Objective
To examine sex differences in the relationship between clinical symptoms related to Alzheimer disease (AD) (verbal memory deficits) and neurodegeneration (hippocampal volume/intracranial volume ratio [HpVR]) across AD stages.Methods
The sample included 379 healthy participants, 694 participants with amnestic mild cognitive impairment (aMCI), and 235 participants with AD and dementia from the Alzheimer's Disease Neuroimaging Initiative who completed the Rey Auditory Verbal Learning Test (RAVLT). Cross-sectional analyses were conducted using linear regression to examine the interaction between sex and HpVR on RAVLT across and within diagnostic groups adjusting for age, education, and APOE ε4 status.Results
Across groups, there were significant sex × HpVR interactions for immediate and delayed recall (p < 0.01). Women outperformed men among individuals with moderate to larger HpVR, but not among individuals with smaller HpVR. In diagnosis-stratified analyses, the HpVR × sex interaction was significant in the aMCI group, but not in the control or AD dementia groups, for immediate and delayed recall (p < 0.01). Among controls, women outperformed men on both outcomes irrespective of HpVR (p < 0.001). In AD dementia, better RAVLT performance was independently associated with female sex (immediate, p = 0.04) and larger HpVR (delayed, p = 0.001).Conclusion
Women showed an advantage in verbal memory despite evidence of moderate hippocampal atrophy. This advantage may represent a sex-specific form of cognitive reserve delaying verbal memory decline until more advanced disease stages.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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