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Laser Treatment of Hypopigmentation in Scars: A Review.
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https://doi.org/10.1097/dss.0000000000003330Abstract
Background
Despite history of multiple treatment modalities, repigmentation of hypopigmented scars remains a difficult clinical problem.Objective
The purpose of this review is to evaluate the literature on laser and combination laser plus adjunct topical therapy for hypopigmented burn and traumatic scars.Materials and methods
A search on PubMed and on Oxford Academic was conducted with additional relevant literature obtained from reference lists.Results
Treatment regimens that address hypopigmentation within scars were reviewed. A combination of nonablative fractional or ablative fractional laser treatment with topical prostaglandin analogue with or without topical retinoid were found to result in superior repigmentation.Conclusion
Reliable improvement of hypopigmentation in scars after laser treatment is challenging. Laser can achieve success in some cases. Ultraviolet laser can achieve modest repigmentation; however, results are short-lived and require continued re-treatment. Modest improvement in pigmentation is seen with nonablative fractional laser or ablative fractional laser alone and enhanced repigmentation is demonstrated when combining fractional laser resurfacing with topical application of synthetic prostaglandin analogues and other known modulators of melanogenesis.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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