Axon loss and neurodegeneration constitute clinically debilitating sequelae in demyelinating diseases such as multiple sclerosis, but the underlying mechanisms of secondary degeneration are not well understood. Myelinating glia play a fundamental role in promoting the maturation of the axon cytoskeleton, regulating axon trafficking parameters, and imposing architectural rearrangements such as the nodes of Ranvier and their associated molecular domains. In the setting of demyelination, these changes may be reversed or persist as maladaptive features, leading to axon degeneration. In this review, we consider recent insights into axon-glial interactions during development and disease to propose that disruption of the cytoskeleton, nodal architecture, and other components of axon infrastructure is a potential mediator of pathophysiological damage after demyelination.

The myth of the deal with the devil at the crossroads frames the reception of Robert Johnson's corpus, particularly lyrics that directly or indirectly reference otherworldly forces. Setting aside the myth, I analyse the uncanny sonic qualities in his performances that evoke a spectral presence. A close examination of vocal and guitar timbre that considers harmonic resonance, chimera effect and other ‘eerie’ qualities of the music breaks down musical elements other than lyrics that evoke the myth of supernatural power. Humming, mumbling and talking, corner loading, falsetto, simultaneous rhythm and lead, among other acoustic effects, contribute to a complex soundscape with spectral resonances. Taking a lead from Johnson's mentor Ike Zimmerman and his fondness for practising in the cemetery, my analysis of timbral quality informed by Freud's concept of the uncanny seeks to explore what we hear, how it is produced and the origin that we construct for the sounds.