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Open Access Publications from the University of California

UCSD Housestaff from multiple disciplines gather to share their contributions to our mission of High Reliability Healthcare.  A sampling of the work presented is featured here.

Syphilis Infection and Increased Odds of Neurologic & Psychiatric Morbidity

(2024)

Background: America is in the midst of a syphilis epidemic. The CDC documented 207,255 new cases of syphilis in 2022, representing the highest incidence of disease observed since 1950 and a 17.3% increase from 2021. Treponemal central nervous system (CNS) invasion is estimated to occur in approximately 25-60% of infections, however, the current standard of care for non-neurologic syphilis does not provide antimicrobial dosing sufficient to achieve CNS clearance. This raises concern for a preventable burden of neurologic morbidity secondary to treponemal CNS persistence and subsequent neurosyphilis. Our central hypothesis is that individuals with a history of syphilis infection will experience greater odds of neurologic morbidity relative to their uninfected counterparts.

Methods: A preliminary 10-year retrospective analysis (01/2013-12/31/2022) of deidentified electronic medical records (EMR) from an academic health system was undertaken. The exposure of interest consisted of grouped ICD-10 codes representative of syphilis infection, with neurologic outcomes defined as ICD-10 diagnoses reflective of the principle clinical manifestations of neurosyphilis. Exploratory analysis of psychiatric outcomes was performed understanding psychiatry to be a property emergent of neurology. Unadjusted, bivariate analysis was performed for preliminary assessment of exposure-outcome association.

Results: 3,619,941 distinct patient EMR were included in the final analysis. 5,943 patients were found to have a diagnosis of syphilis. Patients with a history of syphilis had a higher prevalence of diabetes mellitus (DM), hyperlipidemia (HLD), and HIV relative to patients without a history of syphilis. Additionally, patients with syphilis exposure were found to have significantly higher odds of neurologic morbidity outcomes including stroke (OR = 5.14; 95%CI = 4.71-5.61), dementia (OR = 20.68 ; 95%CI = 19.27–22.19 ), sensorineural hearing loss (OR= 5.75; 95% CI= 5.07-6.2), and blindness (OR= 15.74 ; 95%CI = 14.31-16.54) relative to unexposed patients. Exposed patients also had significantly higher odds of psychiatric morbidity across all mental health outcomes assessed. Sensitivity analysis was performed whereby bivariate exposure-outcome associations were reassessed within a cohort restricted to patients without the potential confounding diagnoses of DM, HLD, and HIV. All neurologic and psychiatric outcomes studied were observed to retain significance during confounder-restricted sensitivity analysis.

Conclusion: Syphilis infection was associated with significantly increased odds of neurologic and psychiatric morbidity across all outcome measures queried after controlling for several potential confounders. These data are concerning as they suggest the possibility of a clinically significant limitation to the neurologic coverage provided by the current standard of care for non-neurologic syphilis. We plan to more rigorously evaluate our hypothesis in a follow-up study that will utilize multivariate logistic regression analysis to more precisely determine the independent effect of syphilis exposure while adjusting for a number of potential confounders.

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Womb to Improve: Assessing needs for a healthier lifestyle during pregnancy 

(2024)

Background: Healthy lifestyle behaviors during pregnancy strongly influence maternal and neonatal outcomes. The UCSD/SDSU General Preventive Medicine Residency (PMR) program partnered with San Diego Family Care, a Federally Qualified Health Center (FQHC) to identify patients’ understandings, barriers, and needs to meet the recommendations for healthy lifestyle behaviors during pregnancy.

Methods: The needs assessment followed the PRECEDE-PROCEED model, and the first three phases used a mixed-method design consisting of social, educational, and ecological assessments. PMR residents and students conducted interviews and focus groups with key stakeholders of the FQHC including maternal health patients, clinicians, and clinic staff and leadership. An environmental survey of the clinic’s catchment area was also performed by PMR residents guided by experts in urban design to assess walkability, safety, and available amenities.

Results: Findings suggest that improved nutrition resources during pregnancy are needed but solutions differed between patients and staff. Clinic staff and leadership were interested in more workers to provide education, while patients requested more information directly from providers. The ecological assessment identified areas of greater walkability and access to healthy food. Overall, the microenvironments discouraged a healthy lifestyle in the local community surrounding the FQHC.

Conclusions: The preliminary results solidify the need to improve resources for maternal nutrition during pregnancy at SDFC. Themes and results from the assessments will be used to inform and design a future intervention. The methods can be used by other sites and FQHCs for ongoing quality improvement and research projects.

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Reducing emergency department and clinic visits for fever in pediatric patients with benign neutropenia: development of a quality improvement project at Rady Children's Hospital San Diego.

(2024)

Issues:Neutropenia can be classified based on pathophysiology as severe versus benign based on bone marrow reserve of neutrophil precursors, which determines the risk of serious bacterial infections (SBI). The current guidelines for management of fever in neutropenic patients are reliant on the knowledge gained in the oncology setting. There are no clear guidelines for management of fever in patients with benign neutropenia regarding evaluation or antibiotic administration, despite their lower risk of SBI. This leads to significant practice variation in management of patients with benign neutropenia who present with fever and may result in unnecessary hospital visits or antibiotic administration, leading to poor quality of life for these patients and avoidable use of healthcare resources. We initiated a quality improvement project to address this issue at Rady Children’s Hospital, San Diego, (RCHSD) with the goal of decreasing the percentage of emergency department (ED) visits for patients with benign neutropenia from a baseline of 60% febrile events to 30% febrile events by May 31, 2025.

 

Description: We collected baseline data via manual chart review from Jan 2023 to Nov 2023 to identify how febrile events were managed in patients with benign neutropenia at RCHSD (Table 1). None of the patients were identified as having a serious bacterial infection. We then sent a survey to all hematology providers at our institution to identify their practice of managing fever in patients with benign neutropenia. Based on the survey results, we created an Ishikawa chart (Figure 1) to identify barriers, and a key driver diagram (Figure 2) to identify possible interventions. We created an ideal process map based on the input from the hematology providers and the proposed algorithm (Figure 3) was agreed upon by the hematology providers.

 

Lessons Learned/Expected Outcomes: Some of the main barriers identified were variation in practices and lack of uniform guidelines in management of fever in patients with benign neutropenia. We plan to use the model of improvement methodology with the key driver diagram to guide improvement efforts.

 

Recommendations: Next steps include presenting the proposed algorithm to the fellows and other providers in the department of hematology-oncology, and to the ED providers before going live with the project. We also plan to present it to general pediatricians at the CPMG (Children’s Physician Medical Group) conference. We will post the algorithm in the inpatient and hematology/oncology clinic workroom and make it easily accessible to all providers on division shared folder. We plan to create a Smart Phrase on EPIC to have a standardized plan in the notes of all patients with a diagnosis of suspected or established benign neutropenia. We will discuss our progress and gain feedback in subsequent QI and division meetings.

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Association between mental health aftercare telephone calls and post-discharge mental health visits for patients on a CL service

(2024)

Background:

Mental health (MH) engagement after discharge from hospitalization is considered an important outcome measure for MH patients. The VA San Diego Healthcare System (VASDHS) has implemented mental health aftercare calls (MHACs) for psychiatric patients discharged from the emergency department, the psychiatric unit, and the medical floors. While every patient discharged from the medical floors receives a primary care aftercare call, only a subset of patients admitted to the medical floors receive MHACs. These patients are identified by a mental health admission diagnosis. In this quality improvement study and innovation, we assess the association between MHACs and the probability of post-discharge MH visits in patients discharged from the medical floors who were seen by the inpatient consult-liaison (CL) psychiatry service.

Description of the Project:

This project is a retrospective review based on encounter codes of an electronic health record for patients admitted to the medical floors at the VASDHS between January-December 2022 who were also seen by the inpatient CL service. The patients who were seen by the CL service were grouped into those who received MHACs and those who did not. Cox regression was used to evaluate the relationship between MHAC and post-discharge likelihood of mental health visit.

Lessons Learned/Expected Outcomes:

386 patients seen by the CL service were identified for analysis. 362 patients did not receive a call and 24 patients did.  After controlling for gender, age, and the number of CL encounters, we found that 51% of patients without a call had a MH visit within 6 months post-discharge, compared with 75% in those patients who were called (HR = 1.3, p>0.05). We found that 33% of patients without a call had a MH visit in the first month post-discharge, compared with 54% in those patients who were called. While these findings were not statistically significant, likely due to low power, this may indicate an increased probability of a MH visit with aftercare calls. 

Recommendations/Next Steps:

Our findings support further analysis and utilization of MHACs for psychiatric patients discharged from the medical floors. The availability of trained mental health nursing staff to conduct MHACs is currently a highly limited resource. Our plan is to develop a systematic protocol for the inpatient CL service to identify patients who they’ve seen who may benefit from a MHAC. This protocol would be used in conjunction with the existing systems-based metrics used to identify patients for MHACs and allow for conscientious utilization of MHACs in post-discharge engagement for psychiatric patients admitted to the medical floors. To identify patients most likely to benefit from MHACs, this protocol should account for patient characteristics such as age, number of recent admissions, MH diagnoses, and/or treatment complexity. Further analysis to assess the efficacy and conscientious use of this valuable staff resource can then be repeated after protocol implementation.

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Screening Out Cancer in Primary Care Settings

(2024)

Background:

Primary care providers (PCPs) address many issues, including cancer prevention and screening, within the limited time available during appointments. Across the San Diego VA Healthcare System, rates of individuals who are up to date with cancer screenings are below the national VA rates. With PCPs being the first line of defense against screening for cancer, it is essential to address this gap in healthcare. This quality improvement project aimed to increase the percentage of up-to-date cancer screenings across multiple cancers (breast, colorectal, cervical, prostate, and lung) among patients at the VA La Jolla Primary Care clinic.

Methods:

We standardized workflow by incorporating cancer screening into the primary care note template to prompt the primary care provider to screen for breast cancer, colorectal cancer, prostate cancer, cervical cancer, and lung cancer. A customized after visit summary (AVS) that included cancer screening was created as part of this project and was given to the patient. The primary outcome was the proportion of cancer screenings completed between October 2023 and March 2024. We analyzed the trend of up-to-date cancer screenings across our patient panel from December 2023 to March 2024.

Results:

Through October 2023 to March 2024, 28 patients were found to be eligible and due for age-appropriate cancer screening, and 43 cancer screening tests were ordered. As of March 2024, 27 of these 43 (63%) tests were completed. Among the study sample, 5/5 (100%) of mammograms were completed, 5/9 (56%) of fecal immunochemical tests were completed, 1/8 (13%) of colonoscopies were completed, 14/16 (88%) of PSA labs were completed, 1/1 (100%) of Pap smears were completed, and 1/4 (25%) of low-dose CTs were completed. From December 2023 to March 2024, screening uptake improved in the three cancer types recorded on the Almanac database. Colorectal cancer screening increased from 48.6% to 50.2%, breast cancer screening increased from 70.4% to 76%, and cervical cancer screening increased from 69.8% to 72.6%.

Conclusions:

Incorporation of cancer screening into the AVS creates a tool that is patient-centered, and this tool has been distributed across the primary care clinic. However, further efforts are needed to increase completion of screening tests. The addition of an automated reminder for lung cancer screening is in progress, and future projects could study the effects of this reminder on screening rates. Completion of cancer screening requires steps outside of the primary care visit, such as scheduling with other departments, and may need to involve further interventions, such as sending a reminder to the patient if a test is not completed within a specific period of time.

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Assessment of Adherence to Status Epilepticus Treatment Guideline after Initiation of Status Epilepticus Order Set 

(2024)

OBJECTIVE An order set was created to optimize the time to administration and ensure proper dosing of benzodiazepine and anti-seizure medications in patients with status epilepticus (SE).

BACKGROUND The Neurocritical Care Society and American Academy of Neurology have developed expert consensus guidelines and quality measures on management of acute SE which recommend that upon seizure onset, benzodiazepines and anti-seizure medications should be administered rapidly (within 5 and 10 minutes, respectively per NCS guidelines) with appropriate weight- based dosing.

DESIGN/METHODS A SE order set was designed in an electronic health record which included pre-determined loading dosages of anti-seizure medications and benzodiazepines in accordance with current guidelines. Education regarding status epilepticus and order set was given to emergency medicine, neurology, neurosurgery, and neurocritical care divisions prior to order set availability in July 2023. We tracked use of the order set in all patients with the diagnosis of SE from July 1, 2023 to October 10, 2023. Our goal was to track the proportion of patients who received benzodiazepines within 5 minutes and anti-seizure medication within 10 minutes of seizure detection, and appropriate first dose of benzodiazepine and anti-seizure medication, before and after order set implementation.

RESULTS The recommended loading dose was used 100% of the time (8/8) with order set use compared to 18% (8/44) without the order set. Recommended benzodiazepine dose was used 50% of the time (2/4) with the order set compared to 64% (28/44) without. Average time to anti-seizure medication administration with the order set was 33 minutes compared to 61 minutes without. Average time to benzodiazepine medication administration was 5 minutes with order set use compared to 9 minutes without.

CONCLUSIONS Our initiative shows there can be improvement in adherence to status epilepticus guideline execution in dosage and time to administration of benzodiazepines and anti-seizure medications with implementation of a standardized SE order set.

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Views on Psychotropics and Lactation Before and After an Educational Intervention

(2024)

Authors: Rachel Dhillon MD, Jessica Kriksciun MD, Ashley Clark MD, Alison Reminick MD, Michelle Singh DO

 

Background: Breastfeeding rates have increased worldwide following advocacy efforts that emphasize the benefits for mother, baby, and society. In the United States there are approximately 500,000 pregnancies in women who have or develop psychiatric illnesses (1). Many of these illnesses benefit from psychotropic medications, and oftentimes these medications are safe to continue during pregnancy and while breastfeeding. Misinformation about the safety profile of psychotropics during lactation can lead to premature discontinuation of medications and worsening of psychiatric symptoms. This can have detrimental consequences for the mother-child dyad and the broader family, as well as societal implications. The aim of this project was to assess the views among psychiatry residents towards psychotropics and lactation before and after a short education intervention. 

 

Methods: We designed a 30 minute lecture for our educational intervention. The topics covered included the benefits of breastfeeding, a summary of key psychotropic medications and their risk/benefit profiles during lactation, key resources to find accurate and comprehensive medication safety data during lactation, and University of California San Diego (UCSD) hospital policies regarding lactation on the inpatient psychiatric unit. The presentation was given two consecutive years to psychiatry interns during protected didactic time; once in February 2023 to seven students and again in March 2024 to six students. Interns were asked to complete a 6 question survey before and after the presentation regarding their views on lactation and psychotropics. Responses were measured using a 5-point Likert Scale and pre and post intervention data was analyzed using paired sample t-tests. 

 

Results: All 13 students completed the pre and post educational intervention questionnaire. There were statistically significant differences (p < 0.01) between pre and post survey ratings for 5 out of the 6 questions. The responses to these questions indicate significant improvement in interns’ comfort and knowledge about the benefits of breastfeeding and considerations for psychotropic medications in this population. There was no statistically significant difference (p = 0.05) in a question about the value of understanding breastfeeding for psychiatric practice. 

 

Conclusions: Our findings suggest that a short educational intervention on psychotropics and lactation can have a profound positive impact on the comfort psychiatry trainees feel addressing and managing such complex considerations.

[1] Crawford-Faucher, A. M. Y. (2010). Safety of Psychotropic Medications in Breastfeeding. American Family Physician, 81(11), 1369-1370.

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Improving Communication in the Operating Room: Interprofessional Simulation Training for General Surgery and Anesthesiology Residents

(2024)

Background:

Bridging the communication gap between General Surgery and Anesthesiology residents is critical for enhancing team performance in emergent situations within the perioperative setting. Historically, these residents have practiced simulation training independently, despite the necessity for interprofessional collaboration in their daily practice. This disconnect can lead to compromised patient safety, poor work relations, and physician burnout.

Description of the Project:

To address this, we introduced an interprofessional simulation training program. The program utilizes high-fidelity mannequins for anesthesiology training and box trainers or live pigs for surgical training. Designed to be appropriate for various training years (Table 1), the simulations were written by anesthesia attendings and residents to focus on joint decision-making, enhancing communication, camaraderie, confidence, and respect among participants. General surgery attendings collaborated with the authors to ensure final simulations were of appropriate complexity and included actionable surgical concerns. Funding is supported by a $10,000 Academy of Clinician Scholars grant.

Lessons Learned/Expected Outcomes:

Post simulation surveys include the NASA Task Load Index (TLI) and questions related to perceived team performance. The TLI is used to measure the effectiveness of the purposefully induced stress response. The remaining questions will be used to assess participants’ perception of their communication, camaraderie, confidence, respect, and understanding of the skills of other team members in the perioperative environment. Longitudinal participation is expected to show significant differences where a single interprofessional simulation event may not. The first series of simulations are incomplete with live animal sessions pending. Once completed, TLI values from live pig sessions will be compared to sessions when they were unavailable or inappropriate. Live animal simulations are expected to increase the stress response of all participants.

No statistically significant differences were observed nor expected with current sample size (62 survey respondents, 45 anesthesia, 17 general surgery). However, interim data analysis does suggest emerging trends. Reported mental demand, temporal demand, effort, and frustration on the TLI decreased with seniority (Figure 1). Surgery reported lower mental demand, temporal demand, effort, and frustration but higher performance demand than anesthesia (Figure 2). Average scores within specialties showed: decreased temporal demand with increased anesthesia year; increased physical and performance demand with surgical year. The data revealed trends of increasing measures of perceived team performance with class year in nearly all categories (Figure 3). No overall trends were observed between specialties (Figure 4). However, increasing averages were observed in all categories when comparing within specialties.

Recommendations/Next Steps:

The project will continue over multiple years to assess longitudinal interprofessional simulation training on medical education. Additional specialties, starting with OB/GYN in the ’24-’25 academic year, will be incorporated. Annual interim data analyses will ensure the program's adaptability and effectiveness. Continuous improvement in simulation scenarios and training methods will be prioritized, with the ultimate goal of establishing a best-practice model for interprofessional simulation training in medical education. This model will be made available to simulation programs at other institutions via a Joint Simulation textbook with Springer Nature.

References:

Not applicable. All content is original authorship by the project team.

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Blood Product and Transfusion Dashboard

(2024)

Background:

Blood product transfusions are one of the most common therapeutic procedures performed in hospitalized patients. Currently, transfusion information is primarily available in UC San Diego’s electronic medical record, EPIC, in a “Transfusion” summary tab. Data available on this tab is incomplete and challenging to navigate. Furthermore, it is difficult to find pertinent blood product data and identify the status of blood product orders in an efficient manner, as data is dispersed throughout multiple locations in EPIC. As a result, delays in blood product transfusions are common. For instance, nurses and providers often call the Blood Bank directly to determine if ordered blood products have been prepared.  Not only does this increase the volume of tasks for clinical team members, the phone calls also disrupt the work of Blood Bank staff, affecting the turnaround time for all orders.  Consequently, blood transfusions may be delayed, at times with life-threatening or fatal consequences.  Another gap in the current EPIC layout is the absence of a quick way to determine if a patient has a history of red cell antibodies, transfusion reactions, or pertinent blood product restrictions.  Without this knowledge, providers may not be aware of patient-specific requirements or extended time required to procure compatible products, which may also delay patient care.   

Description:

The goal of this project is to create a “Blood Product and Transfusion Dashboard” within EPIC, to provide a more efficient way of gathering blood product and transfusion related data and, ultimately, to decrease delays in the transfusion workflow. This will be accomplished by synthesizing data populated in various areas of EPIC and presenting it to providers and nurses in a succinct and readily digestible manner (Figure 1). The dashboard will include pertinent hematologic lab data, with the patient’s hemoglobin, platelets, coagulation factors, haptoglobin, fibrinogen, and type and screen status. It will also include information regarding anticoagulant medications, presence of historical red cell antibodies, and if a consent for transfusion is on file. Beyond this, it will include more intuitive descriptions of product transfusion status: “Ordered”, “Being Prepared”, “Ready for Pickup”, “Transfusing”, or “Transfusion Complete”. Furthermore, the dashboard will leverage data that is actively entered into the patient’s medical record, such as when the clinical team scans a unit, initiates transfusion, and stops the transfusion.

Expected Outcomes:

Multiple benefits are expected with implementation of this dashboard, including decreased time from blood products being ordered to initiation of transfusion, decreased delays in initiating blood product preparation, and improved workflow for nurses, providers, and the Blood Bank staff when determining the status of a blood product order. Overall, these goals should lead to an increase in patient safety and fewer adverse outcomes related to delays in blood product transfusion.

Recommendations:

Next steps involve implementation of the dashboard, while obtaining both timestamp data from EPIC and user survey data to evaluate for potential decreased transfusion delays and improved user experience.

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