Articles

Research works and presentations included here have been selected by the LAUC Research and Professional Development Committee of the UC San Diego Library.

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Making an impact: the new 2024 Medical Library Association research agenda.

(2025)

OBJECTIVE: This research project sought to identify those subject areas that leaders and researcher members of the Medical Library Association (MLA) determined to be of greatest importance for research investigation. It updates two previous studies conducted in 2008 and 2011. METHODS: The project involved a three-step Delphi process aimed at collecting the most important and researchable questions facing the health sciences librarianship profession. First, 495 MLA leaders were asked to submit questions answerable by known research methods. Submitted questions could not exceed 50 words in length. There were 130 viable, unique questions submitted by MLA leaders. Second, the authors asked 200 eligible MLA-member researchers to select the five (5) most important and answerable questions from the list of 130 questions. Third, the same 130 MLA leaders who initially submitted questions were asked to select their top five (5) most important and answerable questions from the 36 top-ranked questions identified by the researchers. RESULTS: The final 15 questions resulting from the three phases of the study will serve as the next priorities of the MLA Research Agenda. The authors will be facilitating the organization of teams of volunteers wishing to conduct research studies related to these identified top 15 research questions. CONCLUSION: The new 2024 MLA Research Agenda will enable the health information professions to allocate scarce resources toward high-yield research studies. The Agenda could be used by journal editors and annual meeting organizers to prioritize submissions for research communications. The Agenda will provide aspiring researchers with some starting points and justification for pursuing research projects on these questions.

Emotional intelligence and happiness: Varied perspectives of supervisors and employees

(2024)

Scholarly Communication Work: On the Ground Perspectives

(2024)

This survey investigates the experiences of scholarly communication workers in North America, with a total of 282 responses. Previous studies on scholarly communication work in academic libraries have tended to focus on organizational structure and necessary competencies. This study aims to put the focus back on workers’ own experiences on the job, to better understand the contributing factors to burnout and attrition that can arise for those in these positions. Five main areas are investigated: newness of the position, scope of the work, support and resources, feelings of one’s expertise being unvalued or dismissed, and the impact of administration. The study concludes with recommendations for library administrators on how to fortify a more sustainable environment for scholarly communication workers.

Energy, Digital Preservation, and the Climate: Proactively Planning for an Uncertain Future

Schaefer, Sibyl

(2024)

Reflecting on the Impact of Hybrid Work on an Academic Library Using the Socio-Ecological Model

(2024)

Covid-19 led to a dramatic change in the academic library work environment, with many workers shifting to a hybrid work schedule once they returned to in person work. The authors describe the impact of this schedule shift through the novel use of the socio-ecological model. The socio-ecological model looks at the impact of choices through varying circles or levels. The authors discuss the individual, interpersonal, community, and societal levels of impact that the switch to hybrid work had within their context and discuss their role as unit leaders and the decisions made to address these varying impacts.

Addressing Equity and Affordability in Digital Study Tools for STEM and the Health Sciences: Possibilities for Library Involvement

(2024)

Students in STEM and the health sciences have unique learning needs, including preparation for exams required for entering a STEM or health sciences profession. Students in these areas thus often seek, in addition to or instead of traditional course materials and library resources, digital study tools that utilize techniques such as spaced repetition. However, such tools are often sold as individual subscriptions that may be prohibitively expensive. The article outlines four approaches libraries may consider to help make digital study tools in STEM and the health sciences more equitable and affordable: assess, adopt, adapt, and create.

Toward Enhanced Reusability: A Comparative Analysis of Metadata for Machine Learning Objects and Their Characteristics in Generalist and Specialist Repositories

(2024)

Objective: The rapidly increasing prevalence and application of machine learning (ML) across disciplines creates a pressing need to establish guidance for data curation professionals. However, we must first understand the characteristics of ML-related objects shared in generalist and specialist repositories and the extent to which repository metadata fields enable findability and reuse of ML objects. Methods: We used a combination of API queries and web scraping to retrieve metadata for ML objects in eight commonly used generalist and ML-specific data repositories. We assessed both metadata schema and characteristics of deposited ML objects, within the context of the widely adopted FAIR Principles. We also calculated summary statistics for properties of objects, including number of objects per year, dataset size, domains represented, and availability of related resources. Results: Generalist repositories excelled at providing provenance metadata, specifically unique identifiers, unambiguous citations, clear licenses, and related resources, while specialist repositories emphasized ML-specific descriptive metadata, such as number of attributes and instances and task type. In terms of object content, we noted a wide range of file formats, as well as licenses, all of which impact reusability. Conclusions: Generalist repositories will benefit from some of the practices adopted by specialists, and specialist repositories will benefit from adopting proven data curation practices of generalist repositories. A step forward for repositories will be to invest more into use of labels and persistent identifiers to improve workflow documentation, provenance, and related resource linking of ML objects, which will increase their findability, interoperability, and reusability.

Acute rotenone poisoning: A scoping review

(2024)

Context

Rotenone is a toxic chemical found in various plants, including some used as food. Rotenone poisoning can be fatal and there is no antidote. Mechanistically, rotenone inhibits mitochondrial complex I, leading to reduced ATP production, compensatory glycolytic upregulation and secondary lactate production, and oxidative stress. Our literature review examined acute rotenone poisoning in humans, including exposure scenarios, clinical presentations, and treatments.

Methods

We searched five databases for relevant literature from database inception through the search date: July 12, 2022, pairing controlled vocabulary and keywords for "rotenone" with terms relating to human exposures and outcomes, such as "ingestion," "exposure," and "poisoning." We included all peer-reviewed reports found using the search terms where the full English text was available. Data abstracted included the number, age, weight, and sex of the exposed person(s), country where exposure happened, exposure scenario, ingestion context, estimated dose, clinical features, whether hospitalization occurred, treatments, and outcomes.

Results

After removing non-qualifying sources from 2,631 publications, we identified 11 case reports describing 18 victims, 15 of whom were hospitalized and five died. Most cases occurred in private quarters where victims unknowingly consumed rotenone-containing plants. Vomiting and metabolic acidosis occurred most commonly. Some patients exhibited impaired cardiopulmonary function. Supportive treatment addressed symptoms and included gastric lavage and/or activated charcoal to remove rotenone from the stomach, vasopressors for hypotension, mechanical ventilation for respiratory insufficiency, and sodium bicarbonate for acidosis. Some patients received N-acetylcysteine to counter oxidative stress.

Conclusions

Rotenone poisoning, though rare, can be fatal. Exposure prevention is impractical since rotenone is found in some plants used as food or pesticides. Cases may be under-diagnosed because symptoms are non-specific and under-reported in English-language journals since most cases occurred in non-English speaking countries. Treatments are supportive. Exploring antioxidant therapy in animal models of rotenone poisoning may be indicated considering rotenone's mechanism of toxicity.

Red Flag Signs and Symptoms for Patients With Early-Onset Colorectal Cancer

(2024)

Importance

Early-onset colorectal cancer (EOCRC), defined as a diagnosis at younger than age 50 years, is increasing, and so-called red flag signs and symptoms among these individuals are often missed, leading to diagnostic delays. Improved recognition of presenting signs and symptoms associated with EOCRC could facilitate more timely diagnosis and impact clinical outcomes.

Objective

To report the frequency of presenting red flag signs and symptoms among individuals with EOCRC, to examine their association with EOCRC risk, and to measure variation in time to diagnosis from sign or symptom presentation.

Data sources

PubMed/MEDLINE, Embase, CINAHL, and Web of Science were searched from database inception through May 2023.

Study selection

Studies that reported on sign and symptom presentation or time from sign and symptom presentation to diagnosis for patients younger than age 50 years diagnosed with nonhereditary CRC were included.

Data extraction and synthesis

Data extraction and quality assessment were performed independently in duplicate for all included studies using Preferred Reporting Items for Systematic Reviews and Meta-analyses reporting guidelines. Joanna Briggs Institute Critical Appraisal tools were used to measure risk of bias. Data on frequency of signs and symptoms were pooled using a random-effects model.

Main outcomes and measures

Outcomes of interest were pooled proportions of signs and symptoms in patients with EOCRC, estimates for association of signs and symptoms with EOCRC risk, and time from sign or symptom presentation to EOCRC diagnosis.

Results

Of the 12 859 unique articles initially retrieved, 81 studies with 24 908 126 patients younger than 50 years were included. The most common presenting signs and symptoms, reported by 78 included studies, were hematochezia (pooled prevalence, 45% [95% CI, 40%-50%]), abdominal pain (pooled prevalence, 40% [95% CI, 35%-45%]), and altered bowel habits (pooled prevalence, 27% [95% CI, 22%-33%]). Hematochezia (estimate range, 5.2-54.0), abdominal pain (estimate range, 1.3-6.0), and anemia (estimate range, 2.1-10.8) were associated with higher EOCRC likelihood. Time from signs and symptoms presentation to EOCRC diagnosis was a mean (range) of 6.4 (1.8-13.7) months (23 studies) and a median (range) of 4 (2.0-8.7) months (16 studies).

Conclusions and relevance

In this systematic review and meta-analysis of patients with EOCRC, nearly half of individuals presented with hematochezia and abdominal pain and one-quarter with altered bowel habits. Hematochezia was associated with at least 5-fold increased EOCRC risk. Delays in diagnosis of 4 to 6 months were common. These findings highlight the need to identify concerning EOCRC signs and symptoms and complete timely diagnostic workup, particularly for individuals without an alternative diagnosis or sign or symptom resolution.

Unit costs of needle and syringe program provision: a global systematic review and cost extrapolation

(2023)

Background

Needle and syringe programs (NSPs) are effective at preventing HIV and hepatitis C virus (HCV) among people who inject drugs (PWID), yet global coverage is low, partly because governments lack data on the cost and cost-effectiveness of NSP in their countries to plan and fund their responses. We conducted a global systematic review of unit costs of NSP provision to inform estimation of cost drivers and extrapolated costs to other countries.

Methods

We conducted a systematic review to extract data on the cost per syringe distributed and its cost drivers. We estimated the impact of country-level and program-level variables on the cost per syringe distributed using linear mixed-effects models. These models were used to predict unit costs of NSP provision, with the best performing model used to extrapolate the cost per syringe distributed for 137 countries. The total cost for a comprehensive NSP (200 syringes per PWID/year) was also estimated for 68 countries with PWID population size estimates.

Results

We identified 55 estimates of the unit cost per syringe distributed from 14 countries. Unit costs were extrapolated for 137 countries, ranging from $0.08 to $20.77 (2020 USD) per syringe distributed. The total estimated spend for a high-coverage, comprehensive NSP across 68 countries with PWID size estimates is $5 035 902 000 for 10 887 500 PWID, 2.1-times higher than current spend.

Conclusion

Our review identified cost estimates from high-income, upper-middle-income, and lower-middle-income countries. Regression models may be useful for estimating NSP costs in countries without data to inform HIV/HCV prevention programming and policy.