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Genetics unravels protein-metabolite relationships.
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https://doi.org/10.1016/j.tem.2024.01.008Abstract
Integrating molecular traits into genetic studies enhances our understanding of how DNA variation influences complex clinical and physiological phenotypes. In a recent article, Benson and colleagues apply this systems genetics approach with proteomics and metabolomics data in plasma from humans to identify and validate several previously unrecognized causal protein-metabolite associations.
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