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Tracking Down Response and Resistance to TRK Inhibitors
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https://doi.org/10.1158/2159-8290.cd-15-1352Abstract
Two recent studies validate the LMNA-NTRK1 fusion as an oncogenic driver and therapeutic target of TRK inhibitors. The LMNA-NTRK1 fusion occurs at low frequency across multiple tumor types. The studies highlight the increasing need to develop molecular biomarker-based clinical trials across cancer subtypes.
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