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Amphotericin B-impregnated bone cement to treat refractory coccidioidal osteomyelitis.
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https://doi.org/10.1128/aac.00963-13Abstract
Use of amphotericin B-impregnated bone cement in combination with systemic antifungals for the treatment of coccidioidal osteomyelitis offers the potential for sustained local concentrations of drug at the site of the infection. Amphotericin B levels in bone of up to 5.1 μg/g have been demonstrated 4 months after placement of bone cement.
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