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Investigation of the relationship between IL-6 and type 2 biomarkers in patients with severe asthma
- Li, Xingnan;
- Hastie, Annette T;
- Peters, Michael C;
- Hawkins, Gregory A;
- Phipatanakul, Wanda;
- Li, Huashi;
- Moore, Wendy C;
- Busse, William W;
- Castro, Mario;
- Erzurum, Serpil C;
- Gaston, Benjamin;
- Israel, Elliot;
- Jarjour, Nizar N;
- Levy, Bruce D;
- Wenzel, Sally E;
- Meyers, Deborah A;
- Fahy, John V;
- Bleecker, Eugene R;
- National Heart, Lung
- et al.
Published Web Location
https://doi.org/10.1016/j.jaci.2019.08.031Abstract
Combination of IL-6 (non-Type 2 asthma) and FeNO or blood eosinophil count (Type 2 asthma) identified asthma endotypes related to asthma severity, exacerbations, and responsiveness to corticosteroids and potential for response to anti-Type 2 and anti-IL-6 treatment.
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