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GD Doped Hollow Silica Shells for Tumor Ablation and MRI
Abstract
Recently, Hollow Silica Shells have been explored for various biomedical applications due to their biocompatibility. Hollow silica shells offer the exibility to adjust their physical and mechanical properties (diameter, shell thickness, shell strength, etc.) as well as their chemical properties via elemental doping or surface chemical modi cation. Hollow silica shells are formed by a unique polymerization reaction between silicic acid into SiO2, creating a layer covering a polystyrene beads as sacri cial templates. The template is then removed via solvent dissolution or heat, yielding a hollow SiO2 shell.