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Structure is beauty, but not always truth.
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https://doi.org/10.1016/j.cell.2024.01.003Abstract
Structural biology, as powerful as it is, can be misleading. We highlight four fundamental challenges: interpreting raw experimental data; accounting for motion; addressing the misleading nature of in vitro structures; and unraveling interactions between drugs and anti-targets. Overcoming these challenges will amplify the impact of structural biology on drug discovery.
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