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Programmable polyketide biosynthesis platform for production of aromatic compounds in yeast
- Jakočiūnas, Tadas;
- Klitgaard, Andreas K;
- Kontou, Eftychia Eva;
- Nielsen, Julie Bang;
- Thomsen, Emil;
- Romero-Suarez, David;
- Blin, Kai;
- Petzold, Christopher J;
- Gin, Jennifer W;
- Tong, Yaojun;
- Gotfredsen, Charlotte Held;
- Charusanti, Pep;
- Frandsen, Rasmus JN;
- Weber, Tilmann;
- Lee, Sang Yup;
- Jensen, Michael K;
- Keasling, Jay D
- et al.
Published Web Location
https://doi.org/10.1016/j.synbio.2020.01.004Abstract
To accelerate the shift to bio-based production and overcome complicated functional implementation of natural and artificial biosynthetic pathways to industry relevant organisms, development of new, versatile, bio-based production platforms is required. Here we present a novel yeast-based platform for biosynthesis of bacterial aromatic polyketides. The platform is based on a synthetic polyketide synthase system enabling a first demonstration of bacterial aromatic polyketide biosynthesis in a eukaryotic host.
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