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CBFB-MYH11 Fusion Transcripts Distinguish Acute Myeloid Leukemias with Distinct Molecular Landscapes and Outcomes
- Huang, Benjamin J;
- Smith, Jenny;
- Wang, Jim;
- Taghizadeh, Kassra;
- Leonti, Amanda R;
- Ries, Rhonda E;
- Liu, Yanling;
- Kolekar, Pandurang;
- Tarlock, Katherine;
- Gerbing, Robert B;
- Crowgey, Erin;
- Furlan, Scott N;
- Shaw, Timothy Isham;
- Hagiwara, Kohei;
- Wei, Lisa;
- Cooper, Todd;
- Gamis, Alan S;
- Aplenc, Richard;
- Kolb, Edward A;
- Farrar, Jason E;
- Triche, Timothy J;
- Alonzo, Todd;
- Ma, Xiaotu;
- Meshinchi, Soheil
- et al.
Published Web Location
https://doi.org/10.1182/bloodadvances.2021004965Abstract
CBFB-MYH11 transcripts and KIT mutations predict relapse in AML. High-risk CBFB-MYH11 transcripts are associated with distinct transcriptional landscapes and upregulation of early hematopoiesis genes.
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