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The genetic architecture of the human cerebral cortex
- Grasby, Katrina L;
- Jahanshad, Neda;
- Painter, Jodie N;
- Colodro-Conde, Lucía;
- Bralten, Janita;
- Hibar, Derrek P;
- Lind, Penelope A;
- Pizzagalli, Fabrizio;
- Ching, Christopher RK;
- McMahon, Mary Agnes B;
- Shatokhina, Natalia;
- Zsembik, Leo CP;
- Thomopoulos, Sophia I;
- Zhu, Alyssa H;
- Strike, Lachlan T;
- Agartz, Ingrid;
- Alhusaini, Saud;
- Almeida, Marcio AA;
- Alnæs, Dag;
- Amlien, Inge K;
- Andersson, Micael;
- Ard, Tyler;
- Armstrong, Nicola J;
- Ashley-Koch, Allison;
- Atkins, Joshua R;
- Bernard, Manon;
- Brouwer, Rachel M;
- Buimer, Elizabeth EL;
- Bülow, Robin;
- Bürger, Christian;
- Cannon, Dara M;
- Chakravarty, Mallar;
- Chen, Qiang;
- Cheung, Joshua W;
- Couvy-Duchesne, Baptiste;
- Dale, Anders M;
- Dalvie, Shareefa;
- de Araujo, Tânia K;
- de Zubicaray, Greig I;
- de Zwarte, Sonja MC;
- Braber, Anouk den;
- Doan, Nhat Trung;
- Dohm, Katharina;
- Ehrlich, Stefan;
- Engelbrecht, Hannah-Ruth;
- Erk, Susanne;
- Fan, Chun Chieh;
- Fedko, Iryna O;
- Foley, Sonya F;
- Ford, Judith M;
- Fukunaga, Masaki;
- Garrett, Melanie E;
- Ge, Tian;
- Giddaluru, Sudheer;
- Goldman, Aaron L;
- Green, Melissa J;
- Groenewold, Nynke A;
- Grotegerd, Dominik;
- Gurholt, Tiril P;
- Gutman, Boris A;
- Hansell, Narelle K;
- Harris, Mathew A;
- Harrison, Marc B;
- Haswell, Courtney C;
- Hauser, Michael;
- Herms, Stefan;
- Heslenfeld, Dirk J;
- Ho, New Fei;
- Hoehn, David;
- Hoffmann, Per;
- Holleran, Laurena;
- Hoogman, Martine;
- Hottenga, Jouke-Jan;
- Ikeda, Masashi;
- Janowitz, Deborah;
- Jansen, Iris E;
- Jia, Tianye;
- Jockwitz, Christiane;
- Kanai, Ryota;
- Karama, Sherif;
- Kasperaviciute, Dalia;
- Kaufmann, Tobias;
- Kelly, Sinead;
- Kikuchi, Masataka;
- Klein, Marieke;
- Knapp, Michael;
- Knodt, Annchen R;
- Krämer, Bernd;
- Lam, Max;
- Lancaster, Thomas M;
- Lee, Phil H;
- Lett, Tristram A;
- Lewis, Lindsay B;
- Lopes-Cendes, Iscia;
- Luciano, Michelle;
- Macciardi, Fabio;
- Marquand, Andre F;
- Mathias, Samuel R;
- Melzer, Tracy R;
- Milaneschi, Yuri;
- Mirza-Schreiber, Nazanin;
- Moreira, Jose CV;
- Mühleisen, Thomas W;
- Müller-Myhsok, Bertram;
- Najt, Pablo;
- Nakahara, Soichiro;
- Nho, Kwangsik;
- Loohuis, Loes M Olde;
- Orfanos, Dimitri Papadopoulos;
- Pearson, John F;
- Pitcher, Toni L;
- Pütz, Benno;
- Quidé, Yann;
- Ragothaman, Anjanibhargavi;
- Rashid, Faisal M;
- Reay, William R;
- Redlich, Ronny;
- Reinbold, Céline S;
- Repple, Jonathan;
- Richard, Geneviève;
- Riedel, Brandalyn C;
- Risacher, Shannon L;
- Rocha, Cristiane S;
- Mota, Nina Roth;
- Salminen, Lauren;
- Saremi, Arvin;
- Saykin, Andrew J;
- Schlag, Fenja;
- Schmaal, Lianne;
- Schofield, Peter R;
- Secolin, Rodrigo;
- Shapland, Chin Yang;
- Shen, Li;
- Shin, Jean;
- Shumskaya, Elena;
- Sønderby, Ida E;
- Sprooten, Emma;
- Tansey, Katherine E;
- Teumer, Alexander;
- Thalamuthu, Anbupalam;
- Tordesillas-Gutiérrez, Diana;
- Turner, Jessica A;
- Uhlmann, Anne;
- Vallerga, Costanza Ludovica;
- van der Meer, Dennis;
- van Donkelaar, Marjolein MJ;
- van Eijk, Liza;
- van Erp, Theo GM;
- van Haren, Neeltje EM;
- van Rooij, Daan;
- van Tol, Marie-José;
- Veldink, Jan H;
- Verhoef, Ellen;
- Walton, Esther;
- Wang, Mingyuan;
- Wang, Yunpeng;
- Wardlaw, Joanna M;
- Wen, Wei;
- Westlye, Lars T;
- Whelan, Christopher D;
- Witt, Stephanie H;
- Wittfeld, Katharina;
- Wolf, Christiane;
- Wolfers, Thomas;
- Wu, Jing Qin;
- Yasuda, Clarissa L;
- Zaremba, Dario;
- Zhang, Zuo;
- Zwiers, Marcel P;
- Artiges, Eric;
- Assareh, Amelia A;
- Ayesa-Arriola, Rosa;
- Belger, Aysenil;
- Brandt, Christine L;
- Brown, Gregory G;
- Cichon, Sven;
- Curran, Joanne E;
- Davies, Gareth E;
- Degenhardt, Franziska;
- Dennis, Michelle F;
- Dietsche, Bruno;
- Djurovic, Srdjan;
- Doherty, Colin P;
- Espiritu, Ryan;
- Garijo, Daniel;
- Gil, Yolanda;
- Gowland, Penny A;
- Green, Robert C;
- Häusler, Alexander N;
- Heindel, Walter;
- Ho, Beng-Choon;
- Hoffmann, Wolfgang U;
- Holsboer, Florian;
- Homuth, Georg;
- Hosten, Norbert;
- JackJr., Clifford R;
- Jang, MiHyun;
- Jansen, Andreas;
- Kimbrel, Nathan A;
- Kolskår, Knut;
- Koops, Sanne;
- Krug, Axel;
- Lim, Kelvin O;
- Luykx, Jurjen J;
- Mathalon, Daniel H;
- Mather, Karen A;
- Mattay, Venkata S;
- Matthews, Sarah;
- Van Son, Jaqueline Mayoral;
- McEwen, Sarah C;
- Melle, Ingrid;
- Morris, Derek W;
- Mueller, Bryon A;
- Nauck, Matthias;
- Nordvik, Jan E;
- Nöthen, Markus M;
- O’Leary, Daniel S;
- Opel, Nils;
- Martinot, Marie-Laure Paillère;
- Pike, G Bruce;
- Preda, Adrian;
- Quinlan, Erin B;
- Rasser, Paul E;
- Ratnakar, Varun;
- Reppermund, Simone;
- Steen, Vidar M;
- Tooney, Paul A;
- Torres, Fábio R;
- Veltman, Dick J;
- Voyvodic, James T;
- Whelan, Robert;
- White, Tonya;
- Yamamori, Hidenaga;
- Adams, Hieab HH;
- Bis, Joshua C;
- Debette, Stephanie;
- Decarli, Charles;
- Fornage, Myriam;
- Gudnason, Vilmundur;
- Hofer, Edith;
- Ikram, M Arfan;
- Launer, Lenore;
- Longstreth, WT;
- Lopez, Oscar L;
- Mazoyer, Bernard;
- Mosley, Thomas H;
- Roshchupkin, Gennady V;
- Satizabal, Claudia L;
- Schmidt, Reinhold;
- Seshadri, Sudha;
- Yang, Qiong;
- Initiative¶, Alzheimer’s Disease Neuroimaging;
- Consortium¶, CHARGE;
- Consortium¶, EPIGEN;
- Consortium¶, IMAGEN;
- Consortium¶, SYS;
- Initiative¶, Parkinson’s Progression Markers;
- Alvim, Marina KM;
- Ames, David;
- Anderson, Tim J;
- Andreassen, Ole A;
- Arias-Vasquez, Alejandro;
- Bastin, Mark E;
- Baune, Bernhard T;
- Beckham, Jean C;
- Blangero, John;
- Boomsma, Dorret I;
- Brodaty, Henry;
- Brunner, Han G;
- Buckner, Randy L;
- Buitelaar, Jan K;
- Bustillo, Juan R;
- Cahn, Wiepke;
- Cairns, Murray J;
- Calhoun, Vince;
- Carr, Vaughan J;
- Caseras, Xavier;
- Caspers, Svenja;
- Cavalleri, Gianpiero L;
- Cendes, Fernando;
- Corvin, Aiden;
- Crespo-Facorro, Benedicto;
- Dalrymple-Alford, John C;
- Dannlowski, Udo;
- de Geus, Eco JC;
- Deary, Ian J;
- Delanty, Norman;
- Depondt, Chantal;
- Desrivières, Sylvane;
- Donohoe, Gary;
- Espeseth, Thomas;
- Fernández, Guillén;
- Fisher, Simon E;
- Flor, Herta;
- Forstner, Andreas J;
- Francks, Clyde;
- Franke, Barbara;
- Glahn, David C;
- Gollub, Randy L;
- Grabe, Hans J;
- Gruber, Oliver;
- Håberg, Asta K;
- Hariri, Ahmad R;
- Hartman, Catharina A;
- Hashimoto, Ryota;
- Heinz, Andreas;
- Henskens, Frans A;
- Hillegers, Manon HJ;
- Hoekstra, Pieter J;
- Holmes, Avram J;
- Hong, L Elliot;
- Hopkins, William D;
- Pol, Hilleke E Hulshoff;
- Jernigan, Terry L;
- Jönsson, Erik G;
- Kahn, René S;
- Kennedy, Martin A;
- Kircher, Tilo TJ;
- Kochunov, Peter;
- Kwok, John BJ;
- Le Hellard, Stephanie;
- Loughland, Carmel M;
- Martin, Nicholas G;
- Martinot, Jean-Luc;
- McDonald, Colm;
- McMahon, Katie L;
- Meyer-Lindenberg, Andreas;
- Michie, Patricia T;
- Morey, Rajendra A;
- Mowry, Bryan;
- Nyberg, Lars;
- Oosterlaan, Jaap;
- Ophoff, Roel A;
- Pantelis, Christos;
- Paus, Tomas;
- Pausova, Zdenka;
- Penninx, Brenda WJH;
- Polderman, Tinca JC;
- Posthuma, Danielle;
- Rietschel, Marcella;
- Roffman, Joshua L;
- Rowland, Laura M;
- Sachdev, Perminder S;
- Sämann, Philipp G;
- Schall, Ulrich;
- Schumann, Gunter;
- Scott, Rodney J;
- Sim, Kang;
- Sisodiya, Sanjay M;
- Smoller, Jordan W;
- Sommer, Iris E;
- St Pourcain, Beate;
- Stein, Dan J;
- Toga, Arthur W;
- Trollor, Julian N;
- Van der Wee, Nic JA;
- van ’t Ent, Dennis;
- Völzke, Henry;
- Walter, Henrik;
- Weber, Bernd;
- Weinberger, Daniel R;
- Wright, Margaret J;
- Zhou, Juan;
- Stein, Jason L;
- Thompson, Paul M;
- Medland, Sarah E;
- group, Enhancing NeuroImaging Genetics through Meta-Analysis Consortium—Genetics working
- et al.
Published Web Location
https://doi.org/10.1126/science.aay6690Abstract
The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder.
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