UCSF

Background: The relationship between stress and quality of life in adults with asthma has not been well studied. Stress, quantified by negative life events, may be linked to quality of life in asthma through multiple pathways, including increase in disease severity and adverse effects on socioeconomic status ( SES). Methods: The responses to a self- completed questionnaire assessing negative life events (NLEs) in the previous 12 months ( from a 24- item checklist) among 189 adults with asthma from a well- characterised cohort were analysed. The relationship between the number of NLEs reported and asthma- specific quality of life ( AQOL) was measured with the Marks instrument. General linear modelling was used to test the conjoint effects of NLEs, SES and disease severity based on the Severity of Asthma Score, a validated acute and chronic disease measure. Results: Those with annual family incomes 80% predicted, nor among those with lower compared with higher Severity of Asthma Score. The frequency of NLEs was associated with poorer ( higher numerical score) AQOL ( p = 0.002). When studied together in the same model, combinations of income level and asthma severity ( greater or lesser Severity of Asthma Score; p < 0.001) and number of NLEs ( p = 0.03) were both significantly associated with AQOL. Conclusion: NLEs are associated with quality of life among adults with asthma, especially among those of lower SES. Clinicians should be aware of this relationship, especially in vulnerable patient subsets.