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HIV-Positive Liver Transplant Does not Alter the Latent Viral Reservoir in Recipients With Antiretroviral Therapy-Suppressed HIV.
- Benner, Sarah;
- Zhu, Xianming;
- Hussain, Sarah;
- Florman, Sander;
- Eby, Yolanda;
- Fernandez, Reinaldo;
- Ostrander, Darin;
- Rana, Meenakshi;
- Ottmann, Shane;
- Hand, Jonathan;
- Price, Jennifer;
- Pereira, Marcus;
- Wojciechowski, David;
- Simkins, Jacques;
- Stosor, Valentina;
- Mehta, Sapna;
- Aslam, Saima;
- Malinis, Maricar;
- Haidar, Ghady;
- Massie, Allan;
- Smith, Melissa;
- Odim, Jonah;
- Morsheimer, Megan;
- Quinn, Thomas;
- Laird, Gregory;
- Siliciano, Robert;
- Balagopal, Ashwin;
- Segev, Dorry;
- Durand, Christine;
- Redd, Andrew;
- Tobian, Aaron
- et al.
Published Web Location
https://doi.org/10.1093/infdis/jiad241Abstract
The latent viral reservoir (LVR) remains a major barrier to HIV-1 curative strategies. It is unknown whether receiving a liver transplant from a donor with HIV might lead to an increase in the LVR because the liver is a large lymphoid organ. We found no differences in intact provirus, defective provirus, or the ratio of intact to defective provirus between recipients with ART-suppressed HIV who received a liver from a donor with (n = 19) or without HIV (n = 10). All measures remained stable from baseline by 1 year posttransplant. These data demonstrate that the LVR is stable after liver transplantation in people with HIV. Clinical Trials Registration. NCT02602262 and NCT03734393.
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