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High yield and high specific activity synthesis of [ 18 F]fallypride in a batch microfluidic reactor for micro-PET imaging

Published Web Location

https://doi.org/10.1039/c3cc47616b
Abstract

[(18)F]fallypride was synthesized in a batch microfluidic chip with a radiochemical yield of 65 ± 6% (n = 7) and an average specific activity of 730 GBq μmol(-1) (20 Ci μmol(-1)) (n = 4). Specific activity was ~2-fold higher than [(18)F]fallypride synthesized in a macroscale radiosynthesizer, despite starting with significantly less radioactivity, and thus safer conditions, in the microchip.

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