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Amyloid-β predominant Alzheimer’s disease neuropathologic change
- Kovacs, Gabor G;
- Katsumata, Yuriko;
- Wu, Xian;
- Aung, Khine Zin;
- Fardo, David W;
- Forrest, Shelley L;
- Bowen, James D;
- Crane, Paul K;
- Jarvik, Gail P;
- Keene, C Dirk;
- Larson, Eric B;
- McCormick, Wayne C;
- McCurry, Susan M;
- Mukherjee, Shubhabrata;
- Kowall, Neil W;
- McKee, Ann C;
- Stern, Robert A;
- Baldwin, Clinton T;
- Farrer, Lindsay A;
- Jun, Gyungah;
- Lunetta, Kathryn L;
- Honig, Lawrence S;
- Vonsattel, Jean Paul;
- Williamson, Jennifer;
- Small, Scott;
- Barral, Sandra;
- Reitz, Christiane;
- Vardarajan, Badri N;
- Mayeux, Richard;
- Burke, James R;
- Hulette, Christine M;
- Welsh-Bohmer, Kathleen A;
- Gearing, Marla;
- Lah, James J;
- Levey, Allan I;
- Wingo, Thomas S;
- Apostolova, Liana G;
- Farlow, Martin R;
- Ghetti, Bernardino;
- Saykin, Andrew J;
- Spina, Salvatore;
- Faber, Kelley M;
- Foroud, Tatiana M;
- Albert, Marilyn S;
- Lyketsos, Constantine G;
- Troncoso, Juan C;
- Frosch, Matthew P;
- Green, Robert C;
- Growdon, John H;
- Hyman, Bradley T;
- Tanzi, Rudolph E;
- Potter, Huntington;
- Dickson, Dennis W;
- Ertekin-Taner, Nilufer;
- Graff-Radford, Neill R;
- Parisi, Joseph E;
- Petersen, Ronald C;
- Boeve, Bradley F;
- Allen, Mariet;
- Carrasquillo, Minerva M;
- Younkin, Steven G;
- Duara, Ranjan;
- Buxbaum, Joseph D;
- Goate, Alison M;
- Sano, Mary;
- Masurkar, Arjun V;
- Wisniewski, Thomas;
- Bigio, Eileen H;
- Mesulam, Marsel;
- Weintraub, Sandra;
- Vassar, Robert;
- Kaye, Jeffrey A;
- Quinn, Joseph F;
- Woltjer, Randall L;
- Barnes, Lisa L;
- Yu, Lei;
- Evans, Denis A;
- Henderson, Victor;
- Fallon, Kenneth B;
- Harrell, Lindy E;
- Marson, Daniel C;
- Roberson, Erik D;
- DeCarli, Charles;
- Jin, Lee-Way;
- Olichney, John M;
- Kim, Ronald;
- LaFerla, Frank M;
- Monuki, Edwin;
- Head, Elizabeth;
- Sultzer, David;
- Geschwind, Daniel H;
- Vinters, Harry V;
- Chesselet, Marie-Francoise;
- Galasko, Douglas R;
- Brewer, James B;
- Boxer, Adam;
- Karydas, Anna;
- Kramer, Joel H;
- Miller, Bruce L;
- Rosen, Howard J;
- Seeley, William W;
- Burns, Jeffrey M;
- Swerdlow, Russell H;
- Van Eldik, Linda J;
- Albin, Roger L;
- Lieberman, Andrew P;
- Paulson, Henry L;
- Arnold, Steven E;
- Trojanowski, John Q;
- Van Deerlin, Vivianna M;
- Cantwell, Laura B;
- Kuzma, Amanda P;
- Malamon, John;
- Naj, Adam C;
- Qu, Liming;
- Schellenberg, Gerard D;
- Valladares, Otto;
- Wang, Li-San;
- Zhao, Yi;
- Hamilton, Ronald L;
- Kamboh, M Ilyas;
- Lopez, Oscar L;
- Becker, James T;
- Cao, Chuanhai;
- Raj, Ashok;
- Smith, Amanda G;
- Chui, Helena C;
- Miller, Carol A;
- Ringman, John M;
- Schneider, Lon S;
- Bird, Thomas D;
- Sonnen, Joshua A;
- Yu, Chang-En;
- Grabowsk, Thomas;
- Peskind, Elaine;
- Raskind, Murray;
- Li, Ge;
- Tsuang, Debby W;
- Asthana, Sanjay;
- Atwood, Craig S;
- Carlsson, Cynthia M;
- Sager, Mark A;
- Chin, Nathaniel A;
- Craft, Suzanne;
- Cairns, Nigel J;
- Morris, John C;
- Cruchaga, Carlos;
- Strittmatter, Stephen;
- Reiman, Eric M;
- Beach, Thomas G;
- Huentelman, Matthew J;
- Hardy, John;
- Kauwe, John SK;
- Hakonarson, Hakon;
- Blacker, Deborah;
- Montine, Thomas J;
- Bush, William S;
- Haines, Jonathan L;
- Lerner, Alan J;
- Zhou, Xiongwei;
- Beecham, Gary W;
- Carney, Regina M;
- Cuccaro, Michael L;
- Gilbert, John R;
- Hamilton-Nelson, Kara L;
- Kunkle, Brian W;
- Martin, Eden R;
- Pericak-Vance, Margaret A;
- Vance, Jeffery M;
- Myers, Amanda J;
- Leverenz, James B;
- De Jager, Philip L;
- Katz, Mindy J;
- Lipton, Richard B;
- Pavlik, Valory;
- Massman, Paul;
- Darby, Eveleen;
- Rodriguear, Monica;
- Khaleeq, Aisha;
- Royall, Donald R;
- Stevens, Alan;
- Ory, Marcia;
- DeToledo, John C;
- Wilms, Henrick;
- Johnson, Kim;
- Perez, Victoria;
- Hernandez, Michelle;
- Wilhelmsen, Kirk C;
- Tilson, Jeffrey;
- Chasse, Scott;
- Barber, Robert C;
- Fairchild, Thomas J;
- O’Bryant, Sid E;
- Knebl, Janice;
- Hall, James R;
- Johnson, Leigh;
- Mains, Douglas;
- Alvarez, Lisa;
- Gamboa, Adriana;
- Paydarfar, David;
- Bertelson, John;
- Woon, Martin;
- Ayres, Gayle;
- Aguirre, Alyssa;
- Palmer, Raymond;
- Polk, Marsha;
- Adams, Perrie M;
- Huebinger, Ryan M;
- Reisch, Joan S;
- Rosenberg, Roger N;
- Cullum, Munro;
- Williams, Benjamin;
- Quiceno, Mary;
- Hynan, Linda;
- Smith, Janet;
- Davis, Barb;
- Nguyen, Trung;
- Rogaeva, Ekaterina;
- George-Hyslop, Peter St;
- Nelson, Peter T
- et al.
Published Web Location
https://doi.org/10.1093/brain/awae325Abstract
Different subsets of Alzheimer's disease neuropathologic change (ADNC), including the intriguing set of individuals with severe/widespread amyloid-β (Aβ) plaques but no/mild tau tangles [Aβ-predominant (AP)-ADNC], may have distinct genetic and clinical features. Analysing National Alzheimer's Coordinating Center data, we stratified 1187 participants into AP-ADNC (n = 95), low Braak primary age-related tauopathy (PART; n = 185), typical-ADNC (n = 832) and high-Braak PART (n = 75). AP-ADNC differed in some clinical features and genetic polymorphisms in the APOE, SNX1, WNT3/MAPT and IGH genes. We conclude that AP-ADNC differs from classical ADNC with implications for in vivo studies.
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