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Common and Divergent Features of Galactose-1-phosphate and Fructose-1-phosphate Toxicity in Yeast
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https://doi.org/10.1091/mbc.e17-11-0666Abstract
Metabolic dysregulation leading to sugar-phosphate accumulation is toxic in organisms ranging from bacteria to humans. By comparing two models of sugar-phosphate toxicity in Saccharomyces cerevisiae, we demonstrate that toxicity occurs, at least in part, through multiple, isomer-specific mechanisms, rather than a single general mechanism.
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