Weaver, Nick A; Zhao, Lei; Biesbroek, J Matthijs; Kuijf, Hugo J; Aben, Hugo P; Bae, Hee‐Joon; Caballero, Miguel ÁA; Chappell, Francesca M; Chen, Christopher PLH; Dichgans, Martin; Duering, Marco; Georgakis, Marios K; van der Giessen, Ruben S; Gyanwali, Bibek; Hamilton, Olivia KL; Hilal, Saima; vom Hofe, Elise M; de Kort, Paul LM; Koudstaal, Peter J; Lam, Bonnie YK; Lim, Jae‐Sung; Makin, Stephen DJ; Mok, Vincent CT; Shi, Lin; Hernández, Maria C Valdés; Venketasubramanian, Narayanaswamy; Wardlaw, Joanna M; Wollenweber, Frank A; Wong, Adrian; Xin, Xu; consortium, Meta VCI Map; DeCarli, C; Fletcher, EA; Maillard, P; Barnes, J; Sudre, CH; Schott, JM; Ikram, MA; Papma, JM; Steketee, RME; Vernooij, MW; Bordet, R; Lopes, R; Huang, C‐W; Frayne, R; McCreary, CR; Smith, EE; group, Calgary Normative Study; Backes, W; Köhler, S; van Oostenbrugge, RJ; Staals, J; Verhey, F; Cheng, CY; Kalaria, RN; Werring, D; Hsu, JL; Huang, K‐L; van der Grond, J; Jukema, JW; van der Mast, RC; Nijboer, TCW; group, Framingham Heart Study; Yu, K‐H; group, The Dutch Parelsnoer Institute–Neurodegenerative diseases; Schmidt, R; Pirpamer, L; MacIntosh, BJ; Robertson, AD; de Leeuw, F‐E; Tuladhar, AM; Chaturvedi, N; Tillin, T; Brodaty, H; Sachdev, P; group, TABASCO; Barkhof, F; van der Flier, WM; Kappelle, LJ; Biessels, Geert Jan

doi:10.1016/j.dadm.2019.02.007

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The Meta VCI Map consortium for meta‐analyses on strategic lesion locations for vascular cognitive impairment using lesion‐symptom mapping: Design and multicenter pilot study

2019

Published Web Location

https://doi.org/10.1016/j.dadm.2019.02.007

Abstract

Introduction

The Meta VCI Map consortium performs meta-analyses on strategic lesion locations for vascular cognitive impairment using lesion-symptom mapping. Integration of data from different cohorts will increase sample sizes, to improve brain lesion coverage and support comprehensive lesion-symptom mapping studies.

Methods

Cohorts with available imaging on white matter hyperintensities or infarcts and cognitive testing were invited. We performed a pilot study to test the feasibility of multicenter data processing and analysis and determine the benefits to lesion coverage.

Results

Forty-seven groups have joined Meta VCI Map (stroke n = 7800 patients; memory clinic n = 4900; population-based n = 14,400). The pilot study (six ischemic stroke cohorts, n = 878) demonstrated feasibility of multicenter data integration (computed tomography/magnetic resonance imaging) and achieved marked improvement of lesion coverage.

Discussion

Meta VCI Map will provide new insights into the relevance of vascular lesion location for cognitive dysfunction. After the successful pilot study, further projects are being prepared. Other investigators are welcome to join.

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