UC Berkeley

Bio-fabrication: Experiments and Experiences in Ethics and Sciences provides an account of an experiment I undertook in ethics and anthropology as part of the International Open Facility Advancing Biotechnology, the BIOFAB. It offers an analysis of the facility's programmatic attempt to actualize a core claim of the new field of synthetic biology: that living beings can be conceived as collections of interoperable genetic components, constructed through rational design, standardized, and fabricated at scale. It provides a diagnosis of the scientific, vocational, and ethical limits of this endeavor. And demonstrates why, in the end, loyalty to truth and seriousness required an exit from the both the mode and stakes of my undertaking.

My experiment with the BIOFAB constituted a distinctive and final phase of a five-year project to design Human Practices, which began as part of the Synthetic Biology Engineering Research Center (SynBERC). Extending ontological and ethical lines of inquiry characteristic of an anthropology of the contemporary, I asked: how are researchers in the BIOFAB bringing things into the world? How are they naming these things, distributing, and modifying them? Equally important, what habits, dispositions, and capacities are being cultivated and managed in order to make such ontological work possible? And, most crucially, what is the price to be paid?

Following intensive participation-observation of the biologists whose task was to put into operation the BIOFAB's strategic vision, the dissertation examines a double-bind at the heart synthetic biology: those who are most capable of taking on the technical challenge of standardizing biological parts are also those least ready to fully commit themselves to such a vision for the future of bioengineering. The ethical and scientific challenge for these biologists was thus how to take a stance toward their work that would simultaneously allow them proceed with a technically difficult experiment, while distancing themselves from the lack of scientific seriousness often attributed to the BIOFAB's undertaking. As the thesis demonstrates, a similar challenge proved equally troublesome for me.

The dissertation concludes that the attempt to incorporate ethics and anthropology as defining elements of synthetic biology reactivates a typically modern problem. Despite efforts to remediate the relations of ethics and science, actual asymmetry in power between biologists and non-biologists encumbers such work. Crucially, the thesis shows that this problem is as characteristic of governance at the highest levels as it is the micro-practices of life in the BIOFAB. In the case of my experiment, such difficulties initially required raising a second-order question: how are asymmetries in power being formed and how might they be unsettled? Ultimately, however, they required an ethics of exit: how can persistent disconnections between power, truth, and ethics be productively refused and, where necessary, left behind?