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Preclinical Development of Tuspetinib for the Treatment of Acute Myeloid Leukemia.
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https://doi.org/10.1158/2767-9764.CRC-24-0258Abstract
This article reports preclinical development of TUS, an oral kinase inhibitor currently in clinical development for treatment of AML. The article covers the studies of TUS activities on cellular targets and the nonclinical studies that supported the advancement of TUS to a phase I/II trial of TUS/VEN in refractory AML and a phase I/II trial of TUS/VEN/5-azacytidine in newly diagnosed patients with AML (NCT03850574).
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