Kun-Rodrigues, Celia; Ross, Owen; Orme, Tatiana; Shepherd, Claire; Parkkinen, Laura; Darwent, Lee; Hernandez, Dena; Ansorge, Olaf; Clark, Lorraine; Honig, Lawrence; Marder, Karen; Lemstra, Afina; Scheltens, Philippe; van der Flier, Wiesje; Louwersheimer, Eva; Holstege, Henne; Rogaeva, Ekaterina; St George-Hyslop, Peter; Londos, Elisabet; Zetterberg, Henrik; Barber, Imelda; Braae, Anne; Brown, Kristelle; Morgan, Kevin; Maetzler, Walter; Berg, Daniela; Troakes, Claire; Al-Sarraj, Safa; Lashley, Tammaryn; Holton, Janice; Compta, Yaroslau; Van Deerlin, Vivianna; Trojanowski, John; Serrano, Geidy; Beach, Thomas; Clarimon, Jordi; Lleó, Alberto; Morenas-Rodríguez, Estrella; Lesage, Suzanne; Galasko, Douglas; Masliah, Eliezer; Santana, Isabel; Diez, Monica; Pastor, Pau; Tienari, Pentti; Myllykangas, Liisa; Oinas, Minna; Revesz, Tamas; Lees, Andrew; Boeve, Brad; Petersen, Ronald; Ferman, Tanis; Escott-Price, Valentina; Graff-Radford, Neill; Cairns, Nigel; Morris, John; Stone, David; Pickering-Brown, Stuart; Mann, David; Dickson, Dennis; Halliday, Glenda; Singleton, Andrew; Guerreiro, Rita; Bras, Jose

doi:10.1016/j.neurobiolaging.2016.08.023

Download PDF

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

2017

Kun-Rodrigues, Celia;
Ross, Owen;
Orme, Tatiana;
Shepherd, Claire;
Parkkinen, Laura;
Darwent, Lee;
Hernandez, Dena;
Ansorge, Olaf;
Clark, Lorraine;
Honig, Lawrence;
Marder, Karen;
Lemstra, Afina;
Scheltens, Philippe;
van der Flier, Wiesje;
Louwersheimer, Eva;
Holstege, Henne;
Rogaeva, Ekaterina;
St George-Hyslop, Peter;
Londos, Elisabet;
Zetterberg, Henrik;
Barber, Imelda;
Braae, Anne;
Brown, Kristelle;
Morgan, Kevin;
Maetzler, Walter;
Berg, Daniela;
Troakes, Claire;
Al-Sarraj, Safa;
Lashley, Tammaryn;
Holton, Janice;
Compta, Yaroslau;
Van Deerlin, Vivianna;
Trojanowski, John;
Serrano, Geidy;
Beach, Thomas;
Clarimon, Jordi;
Lleó, Alberto;
Morenas-Rodríguez, Estrella;
Lesage, Suzanne;
Galasko, Douglas;
Masliah, Eliezer;
Santana, Isabel;
Diez, Monica;
Pastor, Pau;
Tienari, Pentti;
Myllykangas, Liisa;
Oinas, Minna;
Revesz, Tamas;
Lees, Andrew;
Boeve, Brad;
Petersen, Ronald;
Ferman, Tanis;
Escott-Price, Valentina;
Graff-Radford, Neill;
Cairns, Nigel;
Morris, John;
Stone, David;
Pickering-Brown, Stuart;
Mann, David;
Dickson, Dennis;
Halliday, Glenda;
Singleton, Andrew;
Guerreiro, Rita;
Bras, Jose
et al.

Published Web Location

https://doi.org/10.1016/j.neurobiolaging.2016.08.023

Abstract

C9orf72 repeat expansions are a common cause of amyotrophic lateral sclerosis and frontotemporal dementia. To date, no large-scale study of dementia with Lewy bodies (DLB) has been undertaken to assess the role of C9orf72 repeat expansions in the disease. Here, we investigated the prevalence of C9orf72 repeat expansions in a large cohort of DLB cases and identified no pathogenic repeat expansions in neuropathologically or clinically defined cases, showing that C9orf72 repeat expansions are not causally associated with DLB.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content

For improved accessibility of PDF content, download the file to your device.

UC San Diego

Analysis of C9orf72 repeat expansions in a large international cohort of dementia with Lewy bodies.

Published Web Location