Skip to main content
Download PDF
- Main
Amyloid pathology and vascular risk are associated with distinct patterns of cerebral white matter hyperintensities: A multicenter study in 3132 memory clinic patients
- Biesbroek, J Matthijs;
- Coenen, Mirthe;
- DeCarli, Charles;
- Fletcher, Evan M;
- Maillard, Pauline M;
- Initiative, Alzheimer's Disease Neuroimaging;
- Barkhof, Frederik;
- Barnes, Josephine;
- Benke, Thomas;
- Chen, Christopher PLH;
- Dal‐Bianco, Peter;
- Dewenter, Anna;
- Duering, Marco;
- Enzinger, Christian;
- Ewers, Michael;
- Exalto, Lieza G;
- Franzmeier, Nicolai;
- Hilal, Saima;
- Hofer, Edith;
- Koek, Huiberdina L;
- Maier, Andrea B;
- McCreary, Cheryl R;
- Papma, Janne M;
- Paterson, Ross W;
- Pijnenburg, Yolande AL;
- Rubinski, Anna;
- Schmidt, Reinhold;
- Schott, Jonathan M;
- Slattery, Catherine F;
- Smith, Eric E;
- Sudre, Carole H;
- Steketee, Rebecca ME;
- Teunissen, Charlotte E;
- van den Berg, Esther;
- van der Flier, Wiesje M;
- Venketasubramanian, Narayanaswamy;
- Venkatraghavan, Vikram;
- Vernooij, Meike W;
- Wolters, Frank J;
- Xin, Xu;
- Kuijf, Hugo J;
- Biessels, Geert Jan
- et al.
Published Web Location
https://doi.org/10.1002/alz.13765Abstract
Introduction
White matter hyperintensities (WMH) are associated with key dementia etiologies, in particular arteriolosclerosis and amyloid pathology. We aimed to identify WMH locations associated with vascular risk or cerebral amyloid-β1-42 (Aβ42)-positive status.Methods
Individual patient data (n = 3,132; mean age 71.5 ± 9 years; 49.3% female) from 11 memory clinic cohorts were harmonized. WMH volumes in 28 regions were related to a vascular risk compound score (VRCS) and Aß42 status (based on cerebrospinal fluid or amyloid positron emission tomography), correcting for age, sex, study site, and total WMH volume.Results
VRCS was associated with WMH in anterior/superior corona radiata (B = 0.034/0.038, p < 0.001), external capsule (B = 0.052, p < 0.001), and middle cerebellar peduncle (B = 0.067, p < 0.001), and Aß42-positive status with WMH in posterior thalamic radiation (B = 0.097, p < 0.001) and splenium (B = 0.103, p < 0.001).Discussion
Vascular risk factors and Aß42 pathology have distinct signature WMH patterns. This regional vulnerability may incite future studies into how arteriolosclerosis and Aß42 pathology affect the brain's white matter.Highlights
Key dementia etiologies may be associated with specific patterns of white matter hyperintensities (WMH). We related WMH locations to vascular risk and cerebral Aβ42 status in 11 memory clinic cohorts. Aβ42 positive status was associated with posterior WMH in splenium and posterior thalamic radiation. Vascular risk was associated with anterior and infratentorial WMH. Amyloid pathology and vascular risk have distinct signature WMH patterns.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
Main Content
For improved accessibility of PDF content, download the file to your device.
Enter the password to open this PDF file:
File name:
-
File size:
-
Title:
-
Author:
-
Subject:
-
Keywords:
-
Creation Date:
-
Modification Date:
-
Creator:
-
PDF Producer:
-
PDF Version:
-
Page Count:
-
Page Size:
-
Fast Web View:
-
Preparing document for printing…
0%