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Sevelamer Does Not Decrease Lipopolysaccharide or Soluble CD14 Levels But Decreases Soluble Tissue Factor, Low-Density Lipoprotein (LDL) Cholesterol, and Oxidized LDL Cholesterol Levels in Individuals With Untreated HIV Infection
- Sandler, Netanya G;
- Zhang, Xinyan;
- Bosch, Ronald J;
- Funderburg, Nicholas T;
- Choi, Andrew I;
- Robinson, Janet K;
- Fine, Derek M;
- Coombs, Robert W;
- Jacobson, Jeffrey M;
- Landay, Alan L;
- Douek, Daniel C;
- Tressler, Randall;
- Read, Sarah W;
- Wilson, Cara C;
- Deeks, Steven G;
- Lederman, Michael M;
- Gandhi, Rajesh T;
- Tiu, Jennifer;
- Janik, Jennifer;
- Ebiasah, Ruth;
- Sise, Thucuma;
- Morse, Gene;
- Bishopric, George;
- Klebert, Michael;
- Borowski, LuAnn;
- Harding, Paul;
- Gonzalez, Amy;
- Tracy, Russell;
- Claggett, Brian;
- Alvarez, Alicarmen;
- James, Tamara;
- Walton, Patricia;
- Allen, Kristen;
- Daar, Eric;
- Lopez, Ruben;
- Tebas, Pablo;
- Thomas, Aleshia;
- Sbrolla, Amy;
- Flynn, Teri;
- Whitely, Kim;
- Davis, Traci;
- McGregor, Donna;
- Taiwo, Babafemi;
- Hurley, Christine;
- Lake, Jordan;
- Luetkemeyer, Annie;
- Smith, Anna;
- Fichtenbaum, Carl J;
- Stockton, Jan M;
- Griesmer, Kristine;
- Ray, Graham;
- Bolivar, Hector H;
- Fischl, Margaret A;
- Adams, Mary;
- Klebert, Michael K;
- Royal, Michael
- et al.
Published Web Location
https://doi.org/10.1093/infdis/jiu305Abstract
Unlabelled
Abnormal levels of inflammation are associated with cardiovascular disease and mortality in human immunodeficiency virus (HIV)-infected patients. Microbial translocation, which may cause inflammation, is decreased by sevelamer in patients undergoing hemodialysis. In this single-arm study, we evaluated the effects of 8 weeks of sevelamer therapy on 36 HIV-infected subjects who were not receiving antiretroviral therapy. Sevelamer did not significantly change markers of microbial translocation, inflammation, or T-cell activation. During sevelamer treatment, however, levels of soluble tissue factor, low-density lipoprotein (LDL) cholesterol, and oxidized LDL cholesterol decreased significantly, whereas D-dimer levels increased. Thus, in this study population, sevelamer did not reduce microbial translocation but may have yielded cardiovascular benefits.Clinical trials registration
NCT 01543958.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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