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Nuclear Focal Adhesion Kinase Protects against Cisplatin Stress in Ovarian Carcinoma

Published Web Location

https://doi.org/10.1158/2767-9764.crc-24-0382
Abstract

Significance

FAK inhibitors are in combinatorial clinical testing with agents that prevent Ras-Raf-MAPK pathway activation in various cancers. This study suggests that nuclear FAK limits ERK/MAPK activation in supporting HGSOC cell survival to cisplatin stress. Overall, it is likely that targets of FAK-mediated survival signaling may be tumor type- and context-dependent.

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