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Taking Sides: Interferons in Leprosy
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https://doi.org/10.1016/j.chom.2013.04.001Abstract
In a recent Science paper, Teles et al. (2013) show that type I and II interferons (IFNs) are reciprocally expressed in the polar immune forms of leprosy, with type I IFNs inducing IL-10 that interferes with the antimycobacterial effects of type II IFNs (IFNγ) at the site of infection.
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