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Liposomal amphotericin B and complement activation-related pseudoallergy (CARPA).

Published Web Location

https://doi.org/10.1128/aac.01692-24
Abstract

Infusion reactions (tachycardia, hypertension, fever, etc.) associated with liposomal amphotericin B are common. Animal models have found complement activation responsible, yet the pathophysiology has not been evaluated in human patients. We performed a prospective observational study and found complement activation-related pseudoallergy (CARPA) responsible in those with infusion reactions.

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