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Prolonged Tracheal Intubation and the Association Between Patent Ductus Arteriosus and Bronchopulmonary Dysplasia: A Secondary Analysis of the PDA-TOLERATE trial
- Clyman, Ronald I;
- Kaempf, Joseph;
- Liebowitz, Melissa;
- Erdeve, Omer;
- Bulbul, Ali;
- Håkansson, Stellan;
- Lindqvist, Johanna;
- Farooqi, Aijaz;
- Katheria, Anup;
- Sauberan, Jason;
- Singh, Jaideep;
- Nelson, Kelly;
- Wickremasinghe, Andrea;
- Dong, Lawrence;
- Hassinger, Denise C;
- Aucott, Susan W;
- Hayashi, Madoka;
- Heuchan, Anne Marie;
- Carey, William A;
- Derrick, Matthew;
- Fernandez, Erika;
- Sankar, Meera;
- Leone, Tina;
- Perez, Jorge;
- Serize, Arturo;
- Investigators, the PDA-TOLERATE Trial;
- Fields, Scott;
- Whitten, Lora;
- Rogers, Stefanie;
- Okulu, Emel;
- Tunc, Gaffari;
- Ucar, Tayfun;
- Ünal, Ebru Türkoglu;
- Steen, Jane;
- Arnell, Kathy;
- Holtschlag, Sarah;
- Schreiber, Michael;
- Peters, Caryn;
- Gilmore, Maureen;
- McKay, Lorna;
- Carole, Dianne;
- Shaw, Annette;
- Harris, Malinda;
- Amsbaugh, Amy;
- Liedl, Lavonne M;
- Wolf, Sue;
- Groner, Avi;
- Kimball, Amy;
- Kim, Jae;
- Bridge, Renee;
- Knodel, Ellen;
- Weng, Chrissy;
- Barbosa, Magaly Diaz;
- Polin, Richard;
- Weindler, Marilyn;
- Noori, Shahab;
- Reese, Jeffrey;
- Sun, Yao
- et al.
Published Web Location
https://doi.org/10.1016/j.jpeds.2020.09.047Abstract
In the PDA-TOLERATE trial, persistent (even for several weeks) moderate to large patent ductus arteriosus (PDA) was not associated with an increased risk of BPD when the infant required <10 days of intubation. However, in infants requiring intubation for ≥10 days, prolonged PDA exposure (≥11 days) was associated with an increased risk of moderate/severe BPD.
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