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Should Linking Replace Regression When Mapping from Profile-Based Measures to Preference-Based Measures?

Abstract

Background

Profile instruments are frequently used to assess health-related quality of life and other patient-reported outcomes. However, preference-based measures are required for health-economic cost-utility evaluations.

Results

Although regression-based approaches are commonly used to map from profile measures to preference measures, we show that this results in biased estimates because of regression to the mean.

Conclusions

Linking (scale-aligning) is proposed as an alternative.

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