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Gut resistome of preschool children after prolonged mass azithromycin distribution: a cluster-randomized trial
- Arzika, Ahmed M;
- Maliki, Ramatou;
- Abdou, Amza;
- Mankara, Alio K;
- Harouna, Abdoul N;
- Cook, Catherine;
- Hinterwirth, Armin;
- Worden, Lee;
- Zhong, Lina;
- Chen, Cindi;
- Ruder, Kevin;
- Zhou, Zhaoxia;
- Lebas, Elodie;
- O’Brien, Kieran S;
- Oldenburg, Catherine E;
- Le, Victoria;
- Arnold, Benjamin F;
- Porco, Travis;
- Keenan, Jeremy D;
- Lietman, Thomas M;
- Doan, Thuy
- et al.
Published Web Location
https://doi.org/10.1093/cid/ciab485Abstract
We evaluated the gut resistome of children from communities treated with 10 twice-yearly azithromycin distributions. Although the macrolide resistance remained higher in the azithromycin arm, the selection of non-macrolide resistance observed at earlier time points did not persist. Longitudinal resistance monitoring should be a critical component of mass distribution programs.
Clinical trials registration
NCT02047981.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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