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Isolation,of,Binding,Site,of,BMP2,on,CBTerminal,Domain,of,COMP
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Abstract
The use of Bone Morphogenetic Protein clinically is supra-physiologic in concentration.
Bone Morphogenetic Protein 2 (BMP2) is used everyday in orthopaedic surgeries and bone autografts, but it is not used in normal biological amounts.
Clinical uses are 1 million times more than concentrations found physiologically.
Cartilage Oligomeric Matrix Protein (COMP) is known to bind proteins from the TGF superfamily and makes the presentation of BMP2 enhanced due to their binding interaction.
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