The California Conservation Genomics Project (CCGP) is a state-funded initiative with a single goal: to produce the most comprehensive, multispecies, genomic dataset ever assembled to help manage regional biodiversity. The CCGP brings together many of California’s leading experts, working at the interface of genomics and conservation science, to provide decision makers with cutting-edge genomic resources and analyses. Our resources will inform conservation decisions in the face of rapidly accelerating species declines.