Outpatient treatment practices for adolescent substance users utilize retrospective self-report to monitor drug use. Cell phone-based ecological momentary assessment (CEMA) overcomes retrospective self-report biases and can enhance outpatient treatment, particularly among Latino adolescents, who have been understudied with regard to CEMA. This study explores compliance to text message-based CEMA with youth (n = 28; 93% Latino) in outpatient treatment. Participants were rotated through daily, random, and event-based CEMA strategies for 1-month periods. Overall compliance was high (>80%). Compliance decreased slightly over the study period and was less during random versus daily strategies and on days when alcohol use was retrospectively reported. Findings suggest that CEMA is a viable monitoring tool for Latino youth in outpatient treatment, but further study is needed to determine optimal CEMA strategies, monitoring time periods, and the appropriateness of CEMA for differing levels of substance use.

Membrane-associated RING-CH1 (MARCH1) is an E3 ubiquitin ligase that mediates ubiquitination of MHCII in dendritic cells (DCs). MARCH1-mediated MHCII ubiquitination in DCs is known to regulate MHCII surface expression, thereby controlling DC-mediated T cel

BACKGROUND: Congenital scoliosis is a common type of vertebral malformation. Genetic susceptibility has been implicated in congenital scoliosis. METHODS: We evaluated 161 Han Chinese persons with sporadic congenital scoliosis, 166 Han Chinese controls, and 2 pedigrees, family members of which had a 16p11.2 deletion, using comparative genomic hybridization, quantitative polymerase-chain-reaction analysis, and DNA sequencing. We carried out tests of replication using an additional series of 76 Han Chinese persons with congenital scoliosis and a multicenter series of 42 persons with 16p11.2 deletions. RESULTS: We identified a total of 17 heterozygous TBX6 null mutations in the 161 persons with sporadic congenital scoliosis (11%); we did not observe any null mutations in TBX6 in 166 controls (P<3.8×10(-6)). These null alleles include copy-number variants (12 instances of a 16p11.2 deletion affecting TBX6) and single-nucleotide variants (1 nonsense and 4 frame-shift mutations). However, the discordant intrafamilial phenotypes of 16p11.2 deletion carriers suggest that heterozygous TBX6 null mutation is insufficient to cause congenital scoliosis. We went on to identify a common TBX6 haplotype as the second risk allele in all 17 carriers of TBX6 null mutations (P<1.1×10(-6)). Replication studies involving additional persons with congenital scoliosis who carried a deletion affecting TBX6 confirmed this compound inheritance model. In vitro functional assays suggested that the risk haplotype is a hypomorphic allele. Hemivertebrae are characteristic of TBX6-associated congenital scoliosis. CONCLUSIONS: Compound inheritance of a rare null mutation and a hypomorphic allele of TBX6 accounted for up to 11% of congenital scoliosis cases in the series that we analyzed. (Funded by the National Basic Research Program of China and others.).

Radiative decays of the radially excited charmonium resonance, (Formula presented) into (Formula presented) (Formula presented) and (Formula presented) final states have been measured in a sample of (Formula presented) (Formula presented) events collected by the BES Collaboration. The branching ratios (Formula presented) and (Formula presented) are obtained. When compared to the corresponding radiative (Formula presented) decays, the observed (Formula presented) radiative decay rates into (Formula presented) and (Formula presented) are consistent with the prediction of the “12%” rule. © 2003 The American Physical Society.

The cross section for charmed meson production at √s=4.03 and 4.14 GeV has been measured with the Beijing Spectrometer. The measurement was made using 22.3 pb-1 of e+e- data collected at 4.03 GeV and 1.5 pb-1 of e+e- data collected at 4.14 GeV. Inclusive observed cross sections for the production of charged and neutral D mesons and momentum spectra are presented. Observed cross sections were radiatively corrected to obtain tree level cross sections. Measurements of the total hadronic cross section are obtained from the charmed meson cross section and an extrapolation of results from below the charm threshold. ©2000 The American Physical Society.

Using a sample of 3.8 M (Formula presented) events accumulated with the BES detector, the process (Formula presented) is studied. The angular distributions are compared with the general decay amplitude analysis of Cahn. We find that the dipion system requires some D wave amplitude, as well as S wave. On the other hand, the (Formula presented) relative angular momentum is consistent with being pure S wave. The decay distributions have been fit to heavy quarkonium models, including the Novikov-Shifman model. This model, which is written in terms of the parameter (Formula presented) predicts that D wave pions should be present. We determine (Formula presented) based on the joint (Formula presented) distribution. The fraction of D wave amplitude as a function of (Formula presented) is found to decrease with increasing (Formula presented) in agreement with the model. We have also fit the Mannel-Yan model, which is another model that allows D wave pions. © 2000 The American Physical Society.

The branching fraction of the ψ(2S) decay into τ+τ - has been measured for the first time using the BES detector at the Beijing Electron-Positron Collider. The result is Bττ=(2.710. 43±0.55)× 10-3, where the first error is statistical and the second is systematic. This value, along with those for the branching fractions into e+e- and μ+ μ- of this resonance, satisfy well the relation predicted by the sequential lepton hypothesis. Combining all these values with the leptonic width of the resonance, the total width of the ψ(25) is determined to be (252±37) keV. ©2002 The American Physical Society.

The first measurement of (Formula presented) and an upper limit for (Formula presented) are determined from 22.3 (Formula presented) of (Formula presented) annihilation data at a c.m. energy of 4.03 GeV. The data were recorded by the Beijing Spectrometer (BES) at BEPC. A recoil charge method is applied to charm threshold data to determine the charge of the D meson in the recoil from (Formula presented) reconstructed (Formula presented) (Formula presented) mesons. The branching fractions (Formula presented) and (Formula presented) are determined from 10 events with a reconstructed D and a recoiling (Formula presented) In addition, a 90% C.L. upper limit of (Formula presented) is determined from a search for semileptonic decays of the (Formula presented) © 2000 The American Physical Society.

The process e+e−→ pp̄π0has been studied by analyzing data collected at (formula presented) GeV, at (formula presented) GeV, and during a ψ(3770) line shape scan with the BESIII detector at the BEPCII collider. The Born cross section of p̄pπ0in the vicinity of the ψ(3770) is measured, and the Born cross section of ψ(3770) → p̄pπ0is extracted considering interference between resonant and continuum production amplitudes. Two solutions with the same probability and a significance of 1.5 σ are found. The solutions for the Born cross section of ψ(3770) → p̄pπ0are 33.8 ± 1.8 ± 2.1 pb and (formula presented) pb (< 0.22 pb at a 90% confidence level). Using the estimated cross section and a constant decay amplitude approximation, the cross section σ(p̄p → ψ(3770)π0) is calculated for the kinematic situation of the planned P̄ANDA experiment. The maximum cross section corresponding to the two solutions is expected to be less than 0.79 nb at 90% confidence level and 122 ± 10 nb at a center-of-mass energy of 5.26 GeV.

We study D0D̅0 pairs produced in e+e− collisions at √ s = 3.773 GeVusing a data sample of 2.92 fb−1 collected with the BESIII detector. We measuredthe asymmetry ACPKπ of the branching fractions of D → K−π+ in CP-odd and CP-even eigenstates to be (12.7 ± 1.3 ± 0.7) × 10−2. ACPKπ can be used to extract the strong phase difference δKπ between the doubly Cabibbo-suppressed process D̅0 → K−π+ and the Cabibbo-favored process D0 → K−π+. Using world-average values of external parameters, we obtain cos δKπ = 1.02 ±0.11 ±0.06 ±0.01. Here, the first and second uncertainties are statistical and systematic, respectively, while the third uncertainty arises from the external parameters. This is the most precise measurement of δKπ to date.