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Scholarly Works (1 results)

Article
Peer Reviewed

Mutagenesis of the aquaporin 4 extracellular domains defines restricted binding patterns of pathogenic neuromyelitis optica IgG

Verkman, Alan;
Owens, GP;
Ritchie, A;
Rossi, A;
Schaller, K;
Wemlinger, S;
Schumann, H;
Shearer, A;
Verkman, AS;
Bennett, JL

UC San Francisco Previously Published Works (2015)

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.Neuromyelitis optica-immunoglobulin G (NMO-IgG) binds to aquaporin-4 (AQP4) water channels in the central nervous system leading to immune-mediated injury. We have previously demons