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Open Access Publications from the University of California

Scholarly Works (6 results)

  • Article
  • Peer Reviewed
Cliodynamics, Volume 1, Issue 1 (2010)

Among approaches to explaining global history, the secular cycles and leadership long cycle schools emphasize much different phenomena. The former stresses processes highlighting demographic pressures and the rise and fall of land powers. The latter focuses on trading states, maritime activities, and economic growth pulsations. While the two research programs seemingly possess little in common, appearances may be deceiving. By elucidating their overlapping emphasis on structured punctuations in demographic/dynastic cycles with significant changes in global political economy, it is possible to show how the two schools of thought are complementary. A more integrated approach, encompassing population, disease, war and economic growth dynamics, should enhance our understanding of changes in global history.

    Cover page: Synthezing Secular, Demographic-Structural, Climate and Leadership Long Cycles: Moving Toward Explaining Domestic and World Politics in the Last Millennium
    • Article
    • Peer Reviewed
    Cliodynamics, Volume 4, Issue 1 (2013)

    Abstract

    Olsson and Hibbs (2005) and Comin, Easterly, and Gong (2010) make persuasive theoretical and empirical cases for the persistence of early biogeographical and technological advantages in predicting the distribution of national economic wealth. However, these results are challenged with an examination of sixteen observations on economic complexity, GDP per capita, and city size spanning as much as ten millennia and eight to eleven regions. The regional complexity/wealth hierarchies are relatively stable only for finite intervals. Early advantages, thus, have some persistence but do not linger indefinitely. The rich do not always get richer or even stay rich, and the poor sometimes improve their standings in the world pecking order dramatically. Early advantages are important but need to be balanced with the periodic potential for over-riding them.

    • 1 supplemental PDF
    Cover page: Was Wealth Really Determined in 8000 BCE, 1000 BCE, 0 CE, or Even 1500 CE?
    • Peer Reviewed
    UC Irvine Previously Published Works (2017)
    The centrality of domestic coalitions serves as transmission belts between the domestic and international realms. Despite its long lineage in international and comparative political economy and its relevance to the understanding of contemporary responses to globalization, coalitional analysis has been typically neglected when explaining outcomes in international relations. The analytical framework adopted here builds on two “ideal-typical” coalitions—an “inward-nationalist” and an “outward-internationalist” model—each advancing competing models across industrialized and industrializing contexts alike. Several applications illustrate the breadth and scope of this framework, spacious enough to explain economic responses in Europe from the repeal of the Corn Laws to the 20th century; the security implications of economic responses leading to World War I; the impact of internationalization on regional orders in the industrializing world since 1945; the relationship between coalitional approaches to the global economy and nuclear weapons proliferation since 1970; and the relevance of coalitional divides to outcomes regarding Brexit, Donald Trump’s election, and beyond.

    Coalitional analysis thus (a) offers important insights on wide-ranging empirical phenomena in comparative and international politics that institutional approaches alone fail to explain; (b) provides a unifying framework addressing trans-historical responses to globalization, nationalism, ethno-confessionalism, and their effects on interstate relations; (c) attends to political cleavages in political economy that intersect with security; (d) transcends dated level-of-analysis categories by linking subnational and global processes; (e) is flexible enough to accommodate wide variation in state–society relations and political institutionalization; (f) grounds politics in a dynamic framework able to explain both continuity and change; and (g) clarifies contradictory findings regarding interdependence and war by providing a mechanism explaining why, when, and how economic exchange with the world may or may not inhibit war.

      Cover page: Domestic Coalitions: International Sources and EffectsCreative Commons 'BY' version 4.0 license
      • Article
      • Peer Reviewed
      UC San Diego Previously Published Works (2016)
      Achieving functional restoration of diseased or injured tissues is the ultimate goal of both regenerative medicine approaches and physical therapy interventions. Proper integration and healing of the surrogate cells, tissues, or organs introduced using regenerative medicine techniques are often dependent on the co-introduction of therapeutic physical stimuli. Thus, regenerative rehabilitation represents a collaborative approach whereby rehabilitation specialists, basic scientists, physicians, and surgeons work closely to enhance tissue restoration by creating tailored rehabilitation treatments. One of the primary treatment regimens that physical therapists use to promote tissue healing is the introduction of mechanical forces, or mechanotherapies. These mechanotherapies in regenerative rehabilitation activate specific biological responses in musculoskeletal tissues to enhance the integration, healing, and restorative capacity of implanted cells, tissues, or synthetic scaffolds. To become future leaders in the field of regenerative rehabilitation, physical therapists must understand the principles of mechanobiology and how mechanotherapies augment tissue responses. This perspective article provides an overview of mechanotherapy and discusses how mechanical signals are transmitted at the tissue, cellular, and molecular levels. The synergistic effects of physical interventions and pharmacological agents also are discussed. The goals are to highlight the critical importance of mechanical signals on biological tissue healing and to emphasize the need for collaboration within the field of regenerative rehabilitation. As this field continues to emerge, physical therapists are poised to provide a critical contribution by integrating mechanotherapies with regenerative medicine to restore musculoskeletal function.
        Cover page: Understanding Mechanobiology: Physical Therapists as a Force in Mechanotherapy and Musculoskeletal Regenerative Rehabilitation
        • Article
        • Peer Reviewed
        UC Irvine Previously Published Works (2017)

        Purpose of review

        Physical activity improves proximal femoral bone health; however, it remains unclear whether changes translate into a reduction in fracture risk. To enhance any fracture-protective effects of physical activity, fracture prone regions within the proximal femur need to be targeted.

        Recent findings

        The proximal femur is designed to withstand forces in the weight-bearing direction, but less so forces associated with falls in a sideways direction. Sideways falls heighten femoral neck fracture risk by loading the relatively weak superolateral region of femoral neck. Recent studies exploring regional adaptation of the femoral neck to physical activity have identified heterogeneous adaptation, with adaptation principally occurring within inferomedial weight-bearing regions and little to no adaptation occurring in the superolateral femoral neck. There is a need to develop novel physical activities that better target and strengthen the superolateral femoral neck within the proximal femur. Design of these activities may be guided by subject-specific musculoskeletal modeling and finite-element modeling approaches.
          Cover page: Physical Activity for Strengthening Fracture Prone Regions of the Proximal Femur
          • Article
          • Peer Reviewed
          UC Davis Previously Published Works (2019)

          Background

          CRISPR-Cas9 gene-editing technology has facilitated the generation of knockout mice, providing an alternative to cumbersome and time-consuming traditional embryonic stem cell-based methods. An earlier study reported up to 16% efficiency in generating conditional knockout (cKO or floxed) alleles by microinjection of 2 single guide RNAs (sgRNA) and 2 single-stranded oligonucleotides as donors (referred herein as "two-donor floxing" method).

          Results

          We re-evaluate the two-donor method from a consortium of 20 laboratories across the world. The dataset constitutes 56 genetic loci, 17,887 zygotes, and 1718 live-born mice, of which only 15 (0.87%) mice contain cKO alleles. We subject the dataset to statistical analyses and a machine learning algorithm, which reveals that none of the factors analyzed was predictive for the success of this method. We test some of the newer methods that use one-donor DNA on 18 loci for which the two-donor approach failed to produce cKO alleles. We find that the one-donor methods are 10- to 20-fold more efficient than the two-donor approach.

          Conclusion

          We propose that the two-donor method lacks efficiency because it relies on two simultaneous recombination events in cis, an outcome that is dwarfed by pervasive accompanying undesired editing events. The methods that use one-donor DNA are fairly efficient as they rely on only one recombination event, and the probability of correct insertion of the donor cassette without unanticipated mutational events is much higher. Therefore, one-donor methods offer higher efficiencies for the routine generation of cKO animal models.
            Cover page: Reproducibility of CRISPR-Cas9 methods for generation of conditional mouse alleles: a multi-center evaluation
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