A sign change in the Higgs couplings to fermions and massive gauge bosons is still allowed in the framework of two-Higgs doublet models (2HDM). In this work we discuss the possible sign changes in the Higgs couplings to fermions and gaugebosons, while reviewing the status of the 8-parameter CP-conserving 2HDM afterthe Large Hadron Collider 8 TeV run.