INTRODUCTION: This article provides an overview of presentations and discussions from the inaugural Healthcare Delivery Science: Innovation and Partnerships for Health Equity Research (DESCIPHER) Symposium. METHODS: The symposium brought together esteemed experts from various disciplines to explore models for translating evidence-based interventions into practice. RESULTS: The symposium highlighted the importance of disruptive innovation in healthcare, the need for multi-stakeholder engagement, and the significance of family and community involvement in healthcare interventions. CONCLUSIONS: The article concluded with a call to action for advancing healthcare delivery science to achieve health equity.