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Open Access Publications from the University of California

Scholarly Works (2 results)

  • Article
  • Peer Reviewed
UC Irvine Previously Published Works (2005)

Epidemiologic observations and preclinical experimental investigations suggest that the prevention or reversal of precancers should be an effective strategy in humans to control cancer. Although "proof of principle" has been established in humans, the results of randomized trials have not been confirmatory in most cases. Toxicity in normal or near-normal populations has also been greater than anticipated. We examine the problems associated with testing chemoprevention agents in humans and offer a process and guidelines that may better inform the logical development of this relatively young clinical field.

    Cover page: How should we move the field of chemopreventive agent development forward in a productive manner?
    • Article
    • Peer Reviewed
    UC Irvine Previously Published Works (1984)
    An 83-year-old woman with multiple squamous cell carcinomas and keratoacanthomas of the legs was treated with orally administered isotretinoin (13 cis-retinoic acid). Complete regression of the tumors was noted during the initial six-month treatment period. In the subsequent 36 months, four new cutaneous tumors were excised. There have been no recurrences of lesions that regressed while the patient was receiving retinoid therapy.
      Cover page: Oral Isotretinoin Therapy: Use in a Patient With Multiple Cutaneous Squamous Cell Carcinomas and KeratoacanthomasCreative Commons 'BY' version 4.0 license
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