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Open Access Publications from the University of California

Scholarly Works (8 results)

  • Thesis
  • Peer Reviewed
UC San Diego Electronic Theses and Dissertations (2024)

My dissertation defends a non-mechanistic interpretation of Kant’s philosophy of nature. Inspired by the picture of nature in the Critique of Pure Reason and Metaphysical Foundations of Natural Science, most readers align Kant with Early Modern mechanists, who claim that we can know that the internally purposive form of causality characteristic of organisms has no place in nature. To these mechanistic readers, Kant banishes internal purposiveness from nature. To moderate mechanistic interpreters, because we cannot know whether there are internally purposive things in nature and we can demonstrate that mechanism applies to nature, Kant pushes us to believe that any seemingly internally purposive natural products will eventually be explained in mechanistic terms. To strong mechanistic interpreters, Kant gives us the tools to know that there is no room for the special kind of teleology organisms exhibit in nature. My non-mechanistic interpretation rejects this trend by arguing that Kant urges us to believe that the internally purposive activity characteristic of organisms exists in nature. Belief in this context is a firm, positive, and voluntary attitude that aligns with and serves a subject’s interests and ends, and that has implications for the subject’s rational action, assertion, and deliberation. Kant’s stated goal in the third Critique is to bridge the gulf between freedom and nature. My non-mechanistic interpretation offers a new account of how Kant promises to construct this bridge.

    Cover page: Beyond Mechanism: Rethinking Kant’s Philosophy of Nature with the Critique of the Power of Judgment
    • Thesis
    • Peer Reviewed
    UC Santa Barbara Electronic Theses and Dissertations (2023)

    Behavioral parent training programs are effective interventions in addressing a wide range of child behavior problems. Historically, these interventions have engaged a narrowly defined conception of caregivers, focusing on biological mothers, in part due to limited guidance on how to engage other caregivers and utilize their reports of child behavior problems in clinical decision making. Recent advances in methodological strategies to compare agreement between informants in the context of children’s mental health allow us to identify domain-relevant information in instances when disagreement between caregivers yields clinically-relevant information about the child in services. The current study utilized concordance as measured by difference scores and correlations between two caregiver ratings in the context of a parent-child interaction therapy (n = 57). Comparison between concordance at pre-treatment and post-treatment suggest that there was a significant increase in caregiver agreement over the course of treatment for the level of intensity of child behavior problems. Regression models, used to test effects of child and caregiver characteristics on pre- and post-treatment concordance, found that only secondary caregiver stress was significantly associated with caregiver disagreement. A final regression showed that there were no significant predictors in the change in agreement over the course of treatment. Findings provide preliminary evidence of domain-relevant information in regards to multiple caregiver ratings of child behavior problems. Clinical implications, including the importance of capturing when parents might be at risk for ending treatment in lower states of agreement, are discussed.

      Cover page: Caregiver Concordance on Ratings of Child Behavior Problems in Parent-Child Interaction Therapy
      • Article
      • Peer Reviewed
      UC Irvine Previously Published Works (2018)
      Massive Open Online Courses (MOOCs) have the potential to democratize education by providing learners with access to high-quality free online courses. However, evidence supporting this democratization across countries is limited. We explored the question of MOOC democratization by conducting cross-national comparisons of gender differences in the enrollment in and completion of science, technology, engineering, and mathematics (STEM) MOOCs. We found that while females were less likely than males to enroll in STEM MOOCs, they were equally likely to complete them. Further, a higher probability to enroll in STEM MOOCs and smaller gender gaps in STEM MOOC enrollment and completion were found in less gender-equal and less economically developed countries.
        Cover page: Cross-national comparison of gender differences in the enrollment in and completion of science, technology, engineering, and mathematics Massive Open Online Courses
        • Article
        • Peer Reviewed
        UC San Francisco Previously Published Works (2024)

        Background

        Identifying factors associated with post-disaster youth substance use is a crucial element of developing evidence-based prevention and intervention efforts. Hurricane María struck Puerto Rico in September of 2017 and the wide-spread impact from this disaster, including exposure to trauma, displacement, and disrupted social supports had the potential to negatively impact levels of substance use among youth across the archipelago. However, post-disaster substance use remains under-investigated in this context. The current study sought to identify risk and protective factors associated with substance use among Puerto Rican youth in the aftermath of Hurricane Maria.

        Methods

        Cross-sectional, secondary data analyses were conducted using school-based survey data collected at all schools in Puerto Rico between February 1 and June 29, 2018 (5-9 months after Hurricane María). Social supports, substance use, and trauma symptoms were assessed. An ordinal regression analysis was conducted to identify student factors associated with greater likelihood of post-disaster substance use.

        Results

        A total of 36,485 participants (50.7% female, grades 7-12), were included in an ordinal regression analysis that compared the likelihood of respondents endorsing high, low, or no substance use after Hurricane María based on reported adult social support, counselor/teacher social support, peer social support, ptsd symptomatology, and gender. Findings showed that, when compared to students that endorsed low or no substance use, those who reported having adult social support demonstrated a 58% reduction in odds (OR = 0.42, 95% CI: 0.34-0.53) of reporting high substance use after Hurricane María, while students who reported having teacher/counselor social support demonstrated a 21% reduction in odds (OR = 0.79, 95% CI: 0.69-0.89) of reporting high substance use. Additionally, those that reported having peer social support demonstrated a 31% increase in odds (OR = 1.31, 95% CI: 1.10 to 1.58) of reporting higher substance use, compared to those that reported low or no substance use.

        Conclusions

        While social support was generally protective, prevention efforts to build positive family and community connections may be indicated. Evidence-based school screenings of substance use and trauma may help direct intervention to those most at risk for co-occurring issues.
          Cover page: Risk and protective factors associated with substance use among Puerto Rican youths after Hurricane María: a cross-sectional study
          • Article
          • Peer Reviewed
          UC Santa Barbara Previously Published Works (2018)
          This study investigated therapist reports of client engagement challenges in delivering evidence-based practices (EBPs), within the context of a large-scale implementation of multiple practices in children's mental health services. Data were drawn from an online survey of 668 therapists (88% female, 35.0% Non-Hispanic White). The majority of therapists (75.4%) endorsed at least one client engagement challenge during their implementation of an EBP with an identified client over the previous two months. Two types of EBP client engagement challenges with distinct correlates but similar overall frequencies could be readily differentiated - Expressed Client Concerns and Limited Client Engagement in therapy activities. Limited Client Engagement were more commonly reported for clients with externalizing problems and by therapists with higher emotional exhaustion and negative perceptions of the specific EBP being delivered, whereas Hispanic/Latino therapists were less likely to report Limited Client Engagement. In contrast, Expressed Client Concerns were more commonly reported by therapists with positive general attitudes towards EBPs, and among therapists delivering a parent training EBP. Limited Client Engagement but not Expressed Concerns were linked with therapists' self-reported ability to carry out the EBP with the target client. Findings suggest that client engagement challenges are frequent during the delivery of EBPs, but may impact implementation differently based on whether they relate to challenges in engaging clients in therapy activities versus addressing concerns raised by clients.
            Cover page: Community Therapist Reports of Client Engagement Challenges During the Implementation of Multiple EBPs in Children’s Mental Health
            • Article
            • Peer Reviewed
            UC Santa Barbara Previously Published Works (2019)
            This study analyzed qualitative therapist reports of adaptations to the delivery of multiple evidence-based practices (EBPs) within the context of a system-driven reform of children's community mental health services to understand how therapists adapt EBPs as well as contexts of these adaptations to identify when these adaptations are made. The study sought to complement and expand upon previous quantitative survey findings of two categories of Augmenting and Reducing/Reordering adaptations to EBPs. Data included interviews from 60 therapists (88.3% female, 61.7% Latina/o, 80.0% unlicensed) across 20 program sites in 11 mental health agencies that served racial/ethnically diverse children. Interviews were coded to identify themes surrounding the types of adaptations made and the contexts for these adaptations. The majority of therapists' qualitative descriptions of adaptations converged with the 2 broad categories in the Augmenting and Reducing/Reordering Framework, with therapists describing augmenting (e.g., modifying presentation, lengthening or extending pacing) most often, and reducing/reordering adaptations were discussed less frequently. Child and family characteristics were most frequently cited as indications prompting adaptations; however, the specific characteristics motivating adaptations differed by type. Therapists reporting using augmenting adaptations in the context of a wide range of client characteristics, whereas reducing/reordering adaptations occurred more specifically as a function of clinical presentation, family and caregiver functioning, and emergent life events. Therapists described making adaptations to improve the fit of multiple EBPs for the clients they served. Findings could have implications for implementation efforts with diverse clients served in community settings.
              Cover page: Qualitative Reports of How and When Therapists Adapt Children’s Evidence-Based Practices during Community Implementation
              • Article
              • Peer Reviewed
              UC San Diego Previously Published Works (2019)
              Oncodriver genes are usually identified when mutations recur in multiple tumours. Different drivers often converge in the activation or repression of key cancer-relevant pathways. However, as many pathways contain multiple members of the same gene family, individual mutations might be overlooked, as each family member would necessarily have a lower mutation frequency and thus not identified as significant in any one-gene-at-a-time analysis. Here, we looked for mutated, functional sequence positions in gene families that were mutually exclusive (in patients) with another gene in the same pathway, which identified both known and new candidate oncodrivers. For instance, many inactivating mutations in multiple G-protein (particularly Gi/o) coupled receptors, are mutually exclusive with Gαs oncogenic activating mutations, both of which ultimately enhance cAMP signalling. By integrating transcriptomics and interaction data, we show that the Gs pathway is upregulated in multiple cancer types, even those lacking known GNAS activating mutations. This suggests that cancer cells may develop alternative strategies to activate adenylate cyclase signalling in multiple cancer types. Our study provides a mechanistic interpretation for several rare somatic mutations in multi-gene oncodrivers, and offers possible explanations for known and potential off-label cancer treatments, suggesting new therapeutic opportunities.
                Cover page: Rare, functional, somatic variants in gene families linked to cancer genes: GPCR signaling as a paradigm.
                • Article
                • Peer Reviewed
                UCLA Previously Published Works (2022)
                Graphic videos of race-based violence, including police brutality toward Black people and anti-Asian hate crimes, have exploded over the past year. While documentation of these horrific acts has brought visibility to the pervasiveness of racial discrimination, it has also resulted in youth of color being exposed to racial stressors more than ever before across numerous social media and news platforms.1-3 Beyond the significant race-related stress already experienced by youth in school contexts,4 this increased exposure to racism via media is concerning, as both direct and vicarious exposure to racial discrimination can compromise psychological well-being of youth and cause trauma-like symptoms, such as intrusive thoughts, vigilance, and depression.3,5.
                  Cover page: Combating the Conspiracy of Silence: Clinician Recommendations for Talking About Racism-Related Events With Youth of Color
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